In recent years, a wide range of studies have pointed out the importance of nutraceuticals as reservoirs of therapeutic compounds for several diseases, including cancer. This study is centered on the role of some nutraceuticals as anticancer agents and on their efficiency in the oncological gynecological field. Gynecological cancers include cervical, ovarian, and breast neoplasia and these are the major causes of morbidity and mortality in the female population. Cervical neoplasia affects sexually active women aged between 30 and 40 years and is considered the second leading cause of death for women worldwide. Epidemiological studies have shown a strong association of this cancer with human papilloma virus (HPV) infection, independent of any others risk factors. Ovarian cancer represents about 4% of all women’s cancers and breast neoplasia registers 52.8 new cases per 100,000 women annually. Since ancient times, herbal therapies have shown a wide range of beneficial effects and a high potential for safeguarding human health. Azadirachta indica (Neem) is a medicinal plant of Indian origin, a tree with more of 140 isolated compounds and at least 35 biologically active principles that have shown an important influence as tumor suppressors by interfering with the carcinogenesis process. Used for centuries in Asia as a natural remedy for cancer, neem compounds present in bark, leaves, flowers, and seed oil have been shown to possess properties such as chemopreventive capacity, apoptotic activities, immunomodulatory effects, and induction of p53-independent apoptosis. The current study is a systematic literature review based on the anticarcinogenic potential of neem compounds in gynecological cancers.

Ureteral stenting has become one of the most common endoscopic procedure in endourology. Its main purpose is to preserve urinary drainage if this is compromised and maintain a good renal function. Even if there were made significant improvements in the last 50 years, ureteral stenting is not without morbidity. The common ureteral stents cannot have a good long-term efficiency and at some points, it will be blocked by the encrustation and incrustation; as result, the urinary drainage will have to suffer. A total of 134 ureteral stents in 83 patients suffering from reno/ureteral lithiasis were examined. We investigated the risk factors of encrustation and analyzed the chemical compounds of it. A total of 57 stents were found encrusted. The main risk factor was represented by the indwelling time. The rate of encrustation was 18.33% in the first 5 weeks, 56% between week 6 and 12, 75% thereafter. Stents with a smaller caliber (4.8 CH) tend to be more encrusted than those with a bigger one (6 CH). The Fourier Transform Infrared Spectroscopy has found that the main chemical compound of encrustation is represented by calcium oxalate.

The main purpose of study was to gain more comprehensive information about the influence of body mass of water level on some cardiovascular and urinary parameters for the student athletes. Cardiovascular and urinary parameters analysis does not reflect the significant differences between the two samples, but most parameters do not fit into the normal reference values.

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.

Abstract:In order to provide consistent results for biomarkers of cardiac necrosis involved in the early diagnosis of acute myocardial infarction (AMI) and monitoring of patients with acute coronary syndrome (ACS), we carried out in our laboratory a prospective study tracking the influence of two types of preanalytical factors, known as indicators of quality (QIs): hemolysis and immunological status of the patient. We measured plasma levels of cardiac troponin T-TnT (hsst-ECLIA method) and serum levels for enzymatic biomarkers: CKMB (immunoturbidimetric method) associated with total CK and LDH (enzymatic method). The tests were performed after assessing the hemolysis degree through visual inspection of sera/plasma. We compared the results of the measurements performed in non-compliant samples with those obtained for compliant samples (repeated sampling request), and we validated the final analysis report based on available clinical data. The results analysis showed the occurrence of falsely elevated values for CKMB between 200%-700% higher for measurements performed on moderate hemolysed serum. For TnT, we had obtained very high values (even more then 10000 ng/mL), uncorrelated with CK and CKMB levels for patients with malignancy or autoimmune pathology. This preliminary data confirmed the importance of hemolysis degree as criteria for rejecting samples in preanalytical phase and provides premises for further study concerning the influence of immunological status on immunochemical methods for testing cardiac biomarkers.