Background/Aim: The influence of a polyurethanebased tissue adhesive (TissuGlu ® ) on common complications following breast surgery was investigated. Patients and Methods: Within a Randomized-Controlled-Trial 70 women (n=35 TissuGlu ® , n=35 drain) underwent a mastectomy with or without sentinel lymph node excision (SLNE), followed by a 90-day postoperative follow-up. Results: Postoperative interventions: Non-inferiority of the application of TissuGlu ® was seen. Pain-Level/ Hospitalization: A statistically significant pain reduction from day four onwards (p<0.001) and a shorter hospitalization period (p<0.001) was observed. In contrast, the TissuGlu ® group showed increased mean puncture incidence (p=0.013), and increased puncture volume (p=0.021). Conclusion: Application of the polyurethane-based tissue adhesive TissuGlu ® after mastectomy, with or without SLNE, showed potential for improvement of the clinical outcome. In contrast, high intervention rates and increased puncture volume, caused by recurring seromas following application of the surgical adhesive TissuGlu ® , have a negative impact on the patient-specific convalescence.With a prevalence range of 3-85%, seromas are the most frequent postoperative complications following breast surgery (1-4). Up to 15 % of postoperatively developed seromas represent a problem of pronounced clinical relevance due to subsequent complications such as prolonged wound healing, wound infection, secondary wound healing disorders, necrosis, lymphedema, pain, aesthetic deficits and, as a result of this, the delay of any adjuvant therapeutic measures that may subsequently be necessary (1, 5-7). A universally applicable definition of a seroma, beyond the description of the collection of sterile fluid in a surgically preformed wound cavity (the dead space), does not exist in the current literature (2, 5, 8). However, inter alia, proinflammatory and inflammatory exudative and transudative processes in the adjacent tissue, via operative trauma-induced damage, appear to cause the pathophysiological development of seromas (9-12). Additionally, the intraoperative opening of lymphatics and the postoperative movement of the affected extremity, the increased discharge of lymph fluid into the wound area, and the simultaneous reduction of lymph drainage capacity post extensive lymphonodectomy, fosters the development of seromas (7,9,13,14). Many studies have been able to determine other factors that benefit the development of seromas. Along with the type of operation [mastectomy, breast-conserving surgery (BCS) with or without the removal of locoregional lymph nodes (15)], the instruments used also appear to have an impact on seroma formation. It was shown that, to a lesser extent, damage produced mechanically (using a scalpel) and thermally (using electrocauterization) leads to the production and secretion of wound fluid (16,17).Furthermore, various comorbidities [including arterial hypertension (2), elevated BMI (18) and patient-specific characteristics, such as nicotine abuse (18) or a...

Compliance with orthosis therapy and the amount of primary correction are together the most important factors for predicting the final outcome of brace treatment in idiopathic scoliosis. Influencing factors on compliance must be further analyzed.

2 D SWE predicted lesion size more precisely than B-mode ultrasound or mammography. In cases of invasive lobular carcinoma, all three imaging methods underestimated lesion size, with 2 D SWE coming closest to the actual tumor size.

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Background/Aim: The study aimed at investigating the correlation between ductoscopic and histopathological findings and clarify whether the former allow for accurate prediction of malignancy. Patients and Methods: The prospective national multi-center study covered a sample of 224 patients with pathologic nipple discharge. A total of 214 patients underwent ductoscopy with subsequent extirpation of the mammary duct. The ductoscopic findings were categorized according to shape, number, color and surface structure of lesions and vascularity and compared to the histological results and analyses. Results: Ductoscopy revealed lesions in 134 of 214 patients (62.2%). The criteria "multiple versus solitary lesion" differed significantly between malignant and benign lesions. All other criteria were not statistically significant. Malignant tumors were more frequently presented as multiple lesions, benign lesions or masses as solitary lesions (80% vs. 24.8%; p=0.018). Conclusion: The ductoscopic criterion "solitary vs. multiple lesion" appears to have a low diagnostic prediction of malignancy or benignity.Nipple discharge is a common symptom of breast disease. It represents the second leading common symptom after mastodynia for which most women appear in specialized breast departments/clinics (1). A total of 5-7% of all women going to a special breast clinic suffer of nipple discharge (2-4), which may be caused by a benign or malignant lesion. The incidence of pathologic nipple discharge and papilloma has been most frequently described (43-66% of cases), followed by ductal ectasia (15-20%) and carcinomas (10-28%) (1, 2, 4-7). In addition to anamnesis talk and physical examination, further diagnostic methods in cases of pathologic nipple discharge are necessary. These are ultrasound of the breast, mammography, galactography, smear of the nipple, ductal lavage and in some reasonable cases an MRI examination (5,8,9). The whole excision of the secretory duct by using a blue dye technique remains the gold standard for patients with conspicuous nipple discharge. Since the end of the eighties (1980), ductal endoscopy including ductoscopy and galactography is available for a direct visualisation of the small milk ducts (1). Ductoscopy is a minimally invasive endoscopic technique that enables direct intraductal visualization (10). The most promising investigation technique of nipple discharge with unclear causes is actually ductoscopy (1, 2) and has already been 2185