Abstract. Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thyroid receptor (TR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) in malignant breast tumour tissue samples. Patients diagnosed and treated for breast cancer between 1990 and 2000 were included. Receptor expression was detected by immunohistochemical staining.

Biomechanical data interpretation uncovered the pathogenetic relevance of progressive retroflection of the force-displacement-vector. This is responsible for the onset of a vicious cycle of trauma-related force deflection perpetuating pelvic floor traumatization.

Information transfer to patients concerning prenatal medicine is only successful to a certain extent, as pregnant women substantially overrate the risk of congenital handicaps in their fetuses. The need for a more comprehensive instruction of parents is not limited to particular subgroups. Health-care professionals and media are called upon to compensate for the apparent information deficits in parents and improve the public awareness of Down Syndrome.

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