No abstract

Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism and a potent chemoattractant for adult polymorphonuclear leukocytes (PMN). LTB4 may be an important inflammatory mediator in neonatal lung disorders such as bronchopulmonary dysplasia, but neonatal PMN chemotaxis to LTB4 has not been studied. We compared total PMN migration and its components, chemotaxis and chemokinesis, to LTB4 in newborns and adults. PMN from healthy adults and umbilical blood of healthy, full-term newborns (n = 21 pairs) were incubated in a 48-well chemotaxis chamber using 10-microns thick polycarbonate membranes. Membranes with pore sizes of either 3 or 5 microns (diameter) were used to assess the influence of PMN deformability on chemotaxis. For both 3- and 5-microns filter pore sizes, total PMN migration increased in a dose-dependent manner from an LTB4 concentration of 10(-9) to 10(-6) M. The increase in total PMN migration was due entirely to chemotaxis (no chemokinesis) for newborns and adults. However, chemotaxis for the newborn was markedly attenuated, specifically, 14 and 24% of adult values at LTB4 concentrations of 10(-8) and 10(-7) M, respectively, with the 3-microns pore size. With the 5-microns filter pore size, newborn chemotaxis significantly increased to 40 and 49% of adult values at LTB4 concentrations of 10(-8) and 10(-7) M, respectively. We conclude that PMN chemotaxis to LTB4 in vitro is lower in newborns than in adults and part of this impairment may be caused by a decreased deformability of the newborn PMN.(ABSTRACT TRUNCATED AT 250 WORDS)

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. //dx.doi.org/10.17058/reci.v6i4.8290 Páginas 01 de 06 não para fins de citação Justificativa e Objetivos: As doenças periodontais são bastante prevalentes na população, tornando-se fundamental a necessidade de se identificar os aspectos epidemiológicos relacionados a essas patologias. Assim, objetivou-se avaliar se características do estilo de vida, fatores sóciodemográficos e o estado nutricional estariam correlacionados à presença ou não de periodontite, bem como com a sua severidade. Métodos: Trata-se de um estudo transversal com 77 indivíduos (40-70 anos de idade), de ambos os gêneros, voluntários da clínica do Curso de Odontologia da Universidade de Santa Cruz do Sul. Realizou-se um questionário com a história médica, hábito de fumo e álcool, dados socioeconômicos e antropométricos. Clinicamente, executaram-se os exames de profundidade de sondagem, sangramento à sondagem e perda de inserção clínica de todos os dentes presentes na boca dos sujeitos da amostra que foram divididos em três grupos: saúde periodontal, periodontite moderada e periodontite severa. Resultados: A idade média dos indivíduos foi de 52,32±6,86 anos, sendo a maioria do sexo feminino. O predomínio da doença periodontal severa foi na faixa etária entre 50-59 anos, assim como entre aqueles sujeitos com sobrepeso e obesidade. O consumo de fumo e álcool foi pequeno (18% e 11%, respectivamente). Verificou-se uma associação significativa entre a periodontite e o nível socioeconômico, sendo que nas classes A-B1, a maioria dos indivíduos estava com saúde (61%), enquanto que nas classes C2-D-E, a maioria estava com periodontite severa (47%). Conclusão: A população menos favorecida financeiramente teve maior comprometimento periodontal e, mesmo havendo associação com a periodontite, às demais variáveis não apresentaram diferença significativa. Background and Objectives:Periodontal diseases are very prevalent in the population, and it is essential to identify the epidemiological aspects related to these pathologies. Thus, we aimed to evaluate whether lifestyle characteristics, sociodemographic factors and nutritional status would be correlated with the presence or absence of periodontitis, as well as disease severity. Methods: This is a cross-sectional study with 77 subjects (aged 40 to 70 years old) of both genders, volunteers at the Dentistry School Outpatient Clinic of the University of Santa Cruz do Sul. A questionnaire was applied, which included medical history, smoking habit and alcohol consumption, socioeconomic and anthropometric data. Clinically, tests of probing depth, bleeding-to--probing, and loss of clinical insertion of all teeth present in the mouth of the sample subjects were performed, after which the sample was divided into three groups: periodontal health, moderate periodontitis, and severe periodontitis. Results:The mean age of the individuals was 52.32 ± 6.86 years, with most bei...

In view of the current panorama of hospital nutritional care, it is necessary to review nutritional care practices in hospital units, in order to ensure nutritional monitoring and quality of care. Therefore, it is necessary to build flows of nutritional assistance practices at the pediatric hospital level, based on the recommendations of the Federal Council of Nutritionists and the Brazilian Society of Parenteral and Enteral Nutrition, aiming at not generating a deficit in the nutritional monitoring of the patient and in reducing the risk of contamination of the professional. When individual protection equipment is available, nutritional admission will be made in person and during hospitalization, monitoring can be performed using secondary data from electronic medical records and / or telecommunication with the multidisciplinary team. The implementation of nutritional routines in hospitals in times of Covid-19 pandemic generates more assertive conducts for the prevention and treatment of malnutrition and other nutritional implications, also guaranteeing the safety of professionals in assistance in pediatric units..