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SARS-CoV-2 infection in children results in a wide range of clinical outcomes. Paediatric Multisystem Inflammatory syndrome temporally associated with COVID-19(PIMS-TS) occurs weeks after a SARS-CoV-2 infection, and results in severe illness. This protocol describes a study to fully characterize the circulating proteome of children who have PIMS-TS, the proteome of healthy children who have previously been infected with SARS-CoV-2 and the proteome of febrile children with a confirmed invasive infection. Orthogonal proteomic techniques will be utilized to provide a deep proteomic characterization

Total IgE levels are nonspecific and these don't add in management of the patients.Guidelines to prescribe Epipen should be followed and every patient should be given Epipen when indicated.Guidelines for doing Specific IgE testing will be revised will be revised.Re audit will be done in due course to see if the updated guidelines are being implemented.