African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a powerful tool to improve our understanding of the protective immune responses to this complex pathogen; however, previous studies indicated differential vaccine responses after the African swine fever virus challenge of inbred minipigs with different swine leukocyte antigen haplotypes. Lymphocyte numbers and African swine fever virus-specific antibody and T-cell responses were measured in inbred and outbred animals after inoculation with a low virulent African swine fever virus isolate and subsequent challenge with a related virulent virus. Surprisingly, diminished immune responses were observed in the Babraham pigs when compared to the outbred animals, and the inbred pigs were not protected after challenge. Recovery of Babraham pigs after challenge weakly correlated with antibody responses, whereas protective responses in outbred animals more closely correlated with the T-cell response. The Babraham pig may, therefore, represent a useful model for studying the role of antibodies in protection against the African swine fever virus.

No abstract

El pasado junio se realizó el último seminario del proyecto La tradición

This article investigates a planned rebellion in favour of Agustín de Iturbide organised by a group of his supporters in Guadalajara, Jalisco, in 1824. It shows that the rebels in Guadalajara were in close communication with a second cadre of conspirators in Mexico City. By examining the various plans drawn up by the rebels, the article demonstrates the existence of two separate and apparently contradictory aims for the rebellion: the return of Iturbide and the defence of federalism. The question posed by the paper is: does this discovery indicate a coalition between federalists and iturbidistas against the central government in Mexico City?

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