In chronic kidney disease (CKD), oxidative stress (OS) plays a central role in the development of cardiovascular diseases. This pilot program aimed to determine whether an intradialytic aerobic cycling training protocol, by increasing physical fitness, could reduce OS and improve other CKD-related disorders such as altered body composition and lipid profile. Eighteen hemodialysis patients were randomly assigned to either an intradialytic training (cycling: 30 min, 55%-60% peak power, 3 days/week) group (EX; n = 8) or a control group (CON; n = 10) for 3 months. Body composition (from dual-energy X-ray absorptiometry), physical fitness (peak oxygen uptake and the 6-minute walk test (6MWT)), lipid profile (triglycerides (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL)), and pro/antioxidant status (15-F2α-isoprostanes (F2-IsoP) and oxidized LDL in plasma; superoxide dismutase, glutathione peroxidase, and reduced/oxidized glutathione in erythrocytes) were determined at baseline and 3 months later. The intradialytic training protocol did not modify body composition but had significant effects on physical fitness, lipid profile, and pro/antioxidant status. Indeed, at 3 months: (i) performance on the 6MWT was increased in EX (+23.4%, p < 0.001) but did not change in CON, (ii) plasma TG were reduced in EX (-23%, p < 0.03) but were not modified in CON, and (iii) plasma F2-IsoP concentrations were lower in EX than in CON (-35.7%, p = 0.02). In conclusion, our results show that 30 min of intradialytic training, 3 times per week for 3 months, are enough to exert beneficial effects on the most sensitive and reliable marker of lipid peroxidation (IsoP) while improving CKD-associated disorders (lipid profile and physical fitness). Intradialytic aerobic cycling training represents a useful and easy strategy to reduce CKD-associated disorders. These results need to be confirmed with a larger randomized study.

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to Exercise in Physiological and Pathological condition, Clermont Ferrand, FRANCE Introduction and Aims: The aim of the study was to measure the effect of a 3-month High-Intensity Interval Training (HIIT) program on physical functioning, metabolic profile and quality of life in peritoneal dialysis (PD) patients. Methods: Twelve patients (age of 63,89 ± 2,81 years; BMI of 29,42 ± 1,66) were randomly assigned to exercise (EX; n= 8) or control (CON; n= 4) group. The trained patients performed two bicycle-HIIT sessions per week during 12 weeks. HIIT protocol consisted of repeated 8s of sprinting and 12s of turning the pedals over slowly throughout 20 min for a maximum of 60 repeats a session. The HIIT session was followed by 15 min of stretching. Physical functioning ( peak oxygen uptake and the 6-minute walk test (6MWT)), lipid profile (triglycerides (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL)), hemoglobin (Hb) and inflammatory status (CRPus, TNF-α, IL-6, IL-10) were measured before, after the intervention program and 3 months after the end of the intervention program. Energy intake, physical activity level and the quality of life were also evaluated using questionnaires (food questionnaire, IPAQ, SF-36). Results: A significant improvement of 6MWT and improvement of VO 2 peak were observed in the EX group (+ 20% and + 12%, respectively). Lipid profile was not enhanced in the EX group and may be explained by constant levels of energy intake and daily living physical activity. Hemoglobin did not change after the 3-month program in CON or EX group but the mean dose of Erythropoietin Stimulating Agent was reduced in the EX group (-95% against 6% in the CON group). Plasma CRPus, IL-6 and TNF-α levels decreased in the EX group after the HIIT program but remained stable in the CON group. Three months after the intervention program, IL-6 and TNF-α decrease and come back at their initial (M0) value. Plasma IL-10 levels were not altered in any groups. In the EX group, Quality of life was improved for the items representing physical pain limitations (+22,39%), mental pain limitations (+6,25%), relationships (+6,67%) and general health (+2,6%). Conclusions: Our study is the first to demonstrate that a 3-month HIIT program is effective in PD patients to improve physical functioning, inflammation and certain items associated with the quality of life. HIIT appears as a time-efficient strategy and could be proposed in PD patients as an alternative to the classical moderate intensity continuous training (MICT).

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