No abstract

The title compound 3 was prepared in four steps from commercial 3‐amino‐2‐naphthoic acid in an overall 75 % yield. Attempts to use the same approach in the case of 2‐aminonicotinic acid methyl ester failed. All the compounds were characterized by NMR.

New Access to 5-Substituted 1,3-Benzothiazol-2(3H)-ones and Their N-Methyl Analogues by a Palladium Coupling Reaction. -A new route for the synthesis of the title compounds via Stille and Suzuki reactions is presented. -(PIRAT, C.; ULTRE, V.; LEBEGUE, N.; BERTHELOT, P.; YOUS, S.; CARATO*, P.; Synthesis 2011, 3, 480-484, http://dx.doi.org/10.1055/s-0030-1258377 ; Lab. Chim. Ther., Fac. Pharm., Univ. Lille Nord, F-59006 Lille, Fr.; Eng.) -C. Gebhardt

5-Substituted 1,3-benzothiazol-2(3H)-ones and their Nmethyl analogues were readily prepared from the corresponding 5bromo-1,3-benzothiazol-2(3H)-ones by means of Stille and Suzuki reactions. The compounds were substituted at the C-5 position with vinyl, acyl, or aryl groups optionally carrying electron-withdrawing or electron-donating substituents.

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