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Acryloyl monomers have been synthesized by reaction of beta-cyclodextrin and troxerutin with acryloyl chloride and grafted on a knitted material obtained from polyamide 6.6 and polyurethane fibers. Polyamide grafted with beta-cyclodextrin derivative binds troxerutin as a physical complex. The obtained biomaterials have been tested in vivo on rats for their ability to deliver troxerutin (a flebotonic drug) to different skin areas (epidermis, dermis and vascular wall). The results showed that the new synthesized materials can act as multifunctional bioactive textiles that can display both compression (given by the textile material) and sustained venotonic and haemostatic properties (given by the troxerutin delivered from biomaterial to the skin).

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The paper presents the overall results of theoretical achievements and experimental details when designing a material for a textile fabric, which releases a drug for a specific pathology. It presents the conclusions of the researches on the development of textile support as an anti-allergic, anti-fungal and anti-psoriasis type, but also on toxicological, biocompatibility and therapeutic issues for establishing the amount of drug needed for the trans-dermal diffusion. This paper estimates the possibility of applying a cyclodextrin (Cyc) on a textile surface to form temporary reservoirs by complexing and subsequently releasing the drug under the action of cutaneous stimuli. One refers to the achievements of authors, and works submitted by other research groups in the area of textile substrates used as implant or underwear worn next to the skin. The results are analyzed both as a scientific communication and the possible application for a potential current industrial processing.