The Potential of Improving Medical Textile for Cutaneous Diseases

Cyclodextrins – development and applications of these versatile oligosaccharides

“…Moreover, CDs are applied for functionalization of both textiles that can be included inside the body and textiles that come in contact only with the outside surface of the dermis. Hence, they are called implant materials when used for operating at a systemic level (as specific devices such as vascular prostheses, suture threads, stents, or substitutes for tendons) and medical textiles when used on the surface of the body (in knitted, woven, and non-woven structures such as wound dressings, pajamas, tracksuits, caps, socks, gloves, elbow and knee pads, or underwear) (Emam, 2019;Radu et al, 2016;Radu et al, 2017;Reddersen et al, 2016). Therefore, medical textiles find applications in maintaining a good hygiene and health state, but are also used for surgical and therapeutic purposes (Emam, 2019).…”

“…In other words, the physiological perspiration is diffused through the skin, forcing the drug to leave the CD's cavity and transfer itself to the epidermis. The quantity of drug applied is equivalent to the therapeutic dose, with the advantage that the treatment becomes effortless in this way (as the drugs are released even if the patient is unaware of it) (Radu et al, 2016;Radu et al, 2017). Due to the release mechanisms of these textiles, they can be also used for diagnostics purposes, by encapsulating substances present in the patient's sweat within CD cavities (Emam, 2019).…”

“…The medication included in CD medical textiles is usually intended for treating allergies, infectious dermatitis and burns, and also chronic conditions (psoriasis, venous failure, and skin cancer) (Radu et al, 2017). Studies were performed on inclusion of several antiseptics (chlorhexidine diacetate, iodine, and polyhexanide) and there were reported better skin compatibility, higher antimicrobial activity, and enhanced storage stability (Reddersen et al, doi: https://doi.org/10.33263/BTEB71.138150 2016).…”

“…However, they present some disadvantages which restrict their applications; they are insoluble in aqueous media, highly volatile, and degrade under the action of environmental factors (Kfoury et al, 2019). In order to protect essential oils against external factors, but also to ensure a lengthier release, different encapsulation systems can be employed (Radu et al, 2017). CDs represent an excellent candidate for improving the solubility of essential oils, suppressing their volatility and increasing the bioavailability (Moradi et al, 2020).…”

Textile Materials Modified with Stimuli-Responsive Drug Carrier for Skin Topical and Transdermal Delivery

“…Textiles modified with a stimuli-responsive drug carrier have great potential to answer to the specific patient case and can be used as both topical and systemic (transdermal) drug delivery systems [24]. Aromatherapy [25], antimicrobials [26] and painkillers [27], hormone therapy [28], treatment of acne [29] psoriasis [30], atopic dermatitis [31,32], melanoma [33], etc., are just some of the areas where textiles are involved as an important functional element of systems for transdermal therapy, wound dressings, dermatology, etc. The utilization of biomedical textiles in dermatology and transdermal therapy is characterized by easy application, greater comfort and less pain for the patients, their shorter hospitalization, etc.…”