Additively manufactured materials have excellent properties with wide applications in many industries. For designing components exposed to extreme loading situations, it is essential to characterize the high strain rate response of 3D printed (fused deposition modelling) materials. In this study, uniaxial quasi-static and dynamic compressive tests were carried out at various strain rates (10−2 s−1 and 200 s−1 to 1800 s−1) for 3D printed PLA. Strain rate dependent compressive response of Polylactide acid (PLA) disk specimens 3D printed at 0°, 45° and 90° orientations was obtained using the Split Hopkinson bar technique. The results show that the compressive strength increases with corresponding strain rates for 0° and 45° print orientations. PLA printed at 0° has higher compressive strength compared to 45° and 90° orientations under quasi-static as well as high strain rate loading. Toughness was observed to increase with strain rate in all three orientations. A simple modification to the Johnson-Cook model is proposed, which accounts for the effects of print orientation, porosity and strain softening behavior.