Backgroud: Bacteremia and peritonitis caused by Campylobacter jejuni are rarely found in hepatitis B cirrhotic patients, and leukopenia rarely occurs in cases of bacterial infection. Hence, more cases should be shared to improve antibiotic treatment strategies and avoid missed diagnosis in clinical practice. Case presentation: This report shared a case of Campylobacter jejuni infection in hepatitis B cirrhosis with leukopenia that has never been reported in Asia. A 59-year-old with occult hepatitis B cirrhosis was hospitalized due to persistent mild fever and obvious abdominal distention. The patient was diagnosed with bacteremia and spontaneous bacterial peritonitis, and was discharged after treatment with Cefminox Sodium and CefepiMe Hydrochlorid. Conclusion: Parenteral infection with Campylobacter jejuni is more common in patients with decreased immune function. Bacterial infection concealed by leucopenia should be considered to avoid delaying treatment in patients with low immune function.