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BACKGROUND The complex anatomy of root canal makes it very difficult to clean and shape to eliminate the bacteria in the canal. Multiple root canal medicaments and irrigants are used to eliminate the canal microbials. Many of the pathogens have undergone resistance to the medicaments and the irrigants used. Thus, antibacterial nanoparticles have been introduced to overcome this problem. Nano dentistry mainly infers the use of nanomaterials and dental nanorobots in the field of diagnosis and treatment, aiming improvement in complete oral health. The use of nanoparticles is extending in many oral health–related issues such as management of dentin hypersensitivity, elimination of bacterial biofilm, diagnosing as well as treating oral cancers, bone replacement and so on. It possesses a unique physical and chemical property. The usage of nanoparticles in different forms like solutions for irrigation, as intracanal medication, in conjunction with sealers or restorative materials aimed at evaluating and mainly improving the antimicrobial efficacy in endodontic and conservative treatments. These nanoparticles act on the bacteria through various mechanisms. The bactericidal effect of the nanoparticles has been investigated in many in vitro studies. In the field of endodontics, nanomaterials are inculcated mainly focusing on strategies improving antimicrobial efficacy, mechanical integrity of already diseased dentinal matrix, regeneration of the tissues and many more. Recently, many more new technologies are in process to be tested in the field, keeping an eye on overcoming the microbial challenge. This review intended to give a look on the literature available, uses, applications and advantages of the nanoparticles in endodontics. KEY WORDS Nanotechnology, Nanoparticles, Antibacterial Efficacy, Endodontics

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Introduction: Endodontic treatment includes different phases like controlling the growth of microorganism, thorough cleaning and shaping and fluid-tight seal. Sealer plays an important role in Root Canal Treatment (RCT). Sealer fills the space between filling material and dentin. Sealer also acts as a lubricant. Sealer has ability to fill the spaces and prevent microleakege from the root canal. Mineral Trioxide Aggregate (MTA) is a calcium silicate based sealer which has high radiopacity, low solubility and good antibacterial activity. Aim: To evaluate push-out bond strength of MTA as a root canal sealer. Materials and Methods: Studies which were published in English, studies with different years of publication were included. Studies which includes bond strength of MTA as Endodontic Sealer to dentinal wall were also included. Studies used in this review were in-vitro studies and clinical trials. Studies showing tissue toxicity, biocompatibility of MTA were excluded. Also, case reports and in-vivo studies were excluded. All abstracts as well as full texts were studied. PubMed/Medline, Web of Science and Scopus were used for this study. Keywords used were “root canal sealer”, “push-out bond strength”, “MTA”. Total 18 articles were collected. But only five articles fulfilled the inclusion and exclusion criteria. So only five articles were included in this study and discussed in detail. Results: According to the results, of articles which were chosen for this study stated that MTA can be used as an endodontic sealer though it shows lesser push-out bond strength when compared with different newer sealers. Conclusion: In this systematic review, only one in-vitro study showed that Proroot MTA used as root canal sealer exhibits high push-out bond strength than other sealers like MTA Fillapex sealer and AH plus sealer. While MTA Fillapex show lesser push-out bond strength in comparison with other sealers like Proroot MTA sealer, AH plus, Endo CPM sealer. So this systematic review partially fulfills the hypothesis as it gives a utility of Proroot MTA as a root canal sealer.