Nowadays, biomaterials have attained great importance in medical sector owing to the urgent requirement of the material systems which can be suitable for different sorts of human body treatments. Among the various biomaterials available, commercially, polymeric materials occupy great importance because of their near-to-organ characteristics, biocompatibility, corrosion resistance, and other essential mechanical features. The current applications of biopolymers include scaffolding, load-bearing implants, intraocular lenses, artificial heart valves, cardiovascular prostheses, cardiopulmonary bypass, hemodialysis, and dental and orthopedic applications. Although there exist numerous established fabrication routes for biopolymers, yet, their post processing is often required in order to achieve required geometrical and topographical performances. Therefore, machining of the processed biopolymers is often required. The aim of this article was to present a crisp review of the machining of different biopolymers. Further, being an ultraprecision machining operation, specific attention has been paid on the diamond turning technique as well as a case study has been performed to study the effect of process parameters on the resulting characteristics. Overall, the current work will provide a unique platform which could be helpful for young biomedical engineers and scientists focusing on precision surface engineering.