Extensive use of plants belonging to the Bryophyllum species in complementary and alternative therapy has been widely reported. These plants are also used in the treatment of certain diseases like urolithiasis, hypertension and diabetes involving altered kidney function. [1,2] However, systematic and scientific reports on the investigation of K. pinnata for its effects on renal function are scarce. In the present study, an effort has been made to evaluate the effects of the aqueous leaf extract of this plant on gentamicin-induced nephrotoxicity in rats. Gentamicin-induced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions. [3] Hence, in vitro antioxidant activity of this extract has been further investigated. Materials and Methods Plant material Fresh leaves were collected from the herbal garden of our institute and authenticated as K. pinnata (Lam.) Pers.

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