We report the development of a Pd-catalyzed process for the cross coupling of unactivated primary, secondary, and tertiary alkylcarbastannatrane nucleophiles with acyl electrophiles. Reactions involving optically active alkylcarbastannatranes occur with exceptional stereofidelity and with net retention of absolute configuration. Because the stereochemistry of the resulting products is entirely reagent controlled, this process may be viewed as a general, alternative approach to the preparation of products typically accessed via asymmetric enolate methodologies. Additionally, we report a new method for the preparation of optically active alkylcarbastannatranes, which should facilitate their future use in stereospecific reactions.

We report the development of aP d-catalyzed process for the cross coupling of unactivated primary,s econdary,and tertiary alkylcarbastannatrane nucleophiles with acyl electrophiles.R eactions involving optically active alkylcarbastannatranes occur with exceptional stereofidelity and with net retention of absolute configuration. Because the stereochemistry of the resulting products is entirely reagent-controlled, this process may be viewed as ageneral, alternative approach to the preparation of products typically accessed via asymmetric enolate methodologies.A dditionally,w er eport an ew method for the preparation of optically active alkylcarbastannatranes, which should facilitate their future use in stereospecific reactions.