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The gene expression profile has the characteristics of a high dimension, low sample, and continuous type, and it is a great challenge to use gene expression profile data for the classification of tumor samples. This paper proposes a cross-entropy based multi-filter ensemble (CEMFE) method for microarray data classification. Firstly, multiple filters are used to select the microarray data in order to obtain a plurality of the pre-selected feature subsets with a different classification ability. The top N genes with the highest rank of each subset are integrated so as to form a new data set. Secondly, the cross-entropy algorithm is used to remove the redundant data in the data set. Finally, the wrapper method, which is based on forward feature selection, is used to select the best feature subset. The experimental results show that the proposed method is more efficient than other gene selection methods and that it can achieve a higher classification accuracy under fewer characteristic genes.

An optimal weight learning machine with growth of hidden nodes and incremental learning (OWLM-GHNIL) is given by adding random hidden nodes to single hidden layer feedforward networks (SLFNs) one by one or group by group. During the growth of the networks, input weights and output weights are updated incrementally, which can implement conventional optimal weight learning machine (OWLM) efficiently. The simulation results and statistical tests also demonstrate that the OWLM-GHNIL has better generalization performance than other incremental type algorithms.

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