Magnetic-based
theranostics feature a high efficiency, excellent
tissue penetration, and minimal damage to normal tissues, are noninvasive,
and are widely used in the diagnosis and therapy of clinical diseases.
Herein, a conceptually novel magnetostrictive-piezoelectric nanocatalytic
medicine (MPE-NCM) for tumor therapy is proposed by initiating an
intratumoral magneto-driven and piezoelectric-catalyzed reaction using
core–shell structured CoFe2O4–BiFeO3 magnetostrictive-piezoelectric nanoparticles (CFO-BFO NPs)
under an alternating magnetic field. The CFO-BFO NPs catalyze the
generation of cytotoxic reactive oxygen species (ROS): superoxide
radicals (•O2
–) and hydroxyl radicals
(•OH). The simulation calculation demonstrates the highly controllable
electric polarization, facilitating the above catalytic reactions
under the magnetic stimulation. Both a detailed cell-level assessment
and the tumor xenograft evaluation evidence the significant tumor
eradication efficacy of MPE-NCM. This study proposes an original and
novel magneto-responsive nanocatalytic modality for cancer therapy,
which displays promising prospects for the future clinic translation
owing to its excellent catalytic dynamic responsiveness, high therapeutic
efficacy, and biosafety in vivo.
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