Local hypoxia in tumors results in undesirable impediments for the efficiencies of oxygen‐dependent chemical and photodynamic therapy (PDT). Herein, a versatile oxygen‐generating and pH‐responsive nanoplatform is developed by loading MnO2 nanodots onto the nanosystem that encapsulates g‐C3N4 and doxorubicin hydrochloride to overcome the hypoxia‐caused resistance in cancer therapy. The loaded MnO2 nanodots can react with endogenous acidic H2O2 to elevate the dissolved oxygen concentration, leading to considerably enhanced cancer therapy efficacy. As such, the as‐prepared nanoplatform with excellent dispersibility and satisfactory biocompatibility can sustainably increase the oxygen concentration and rapidly release the encapsulated drugs in acid H2O2 environment. In vitro cytotoxicity experiments show a higher therapy effect by the designed nanoplatform, when compared to therapy without MnO2 nanodots under hypoxia condition, or chemical and photodynamic therapy alone with the presence of MnO2 nanodots. In vivo experiments also demonstrate that 4T1 tumors can be very efficiently eliminated by the designed nanoplatform under light irradiation. These results highlight that the MnO2 nanodots‐based nanoplatform is promising for elevating the oxygen level in tumor microenvironments to overcome hypoxia limitations for high‐performance cancer therapy.

The worsening pollution due to mercury species makes it inevitable to explore prospective versatile materials, which not only can detect mercury ions (Hg2+) with high sensitivity but also possesses efficient capture and removal ability. In this study, a series of classic organic ligand-based luminescence MOFs materials with high oxidation state central metals (Al3+, Zr4+, Cr3+, Fe3+, and Ti4+) were synthesized and were screened to achieve simultaneously Hg2+ detection and removal through the strong coordination of amino groups or nitrogen centers with Hg2+ and the intrinsic fluorescence intensity of MOFs regulated by the ligand-to-metal charge transfer (LMCT) effect. Among these checked materials, NH2-MIL-53­(Al) exhibited the excellent ability for Hg2+ detection with wide response interval (1–17.3 μM), low detection limit (0.15 μM), good selectivity, wide pH adaptation (4.0–10.0), and strong anti-interference ability. Meanwhile, the resultant NH2-MIL-53­(Al) possessed an efficient removal capability toward Hg2+, accompanied by a fast uptake kinetics (within 60 min) and large loading capacity (153.85 mg g–1). Furthermore, NH2-MIL-53­(Al) also displayed satisfactory stability before and after Hg2+ treatment because of the formation of strong coordination bonds between high oxidation state aluminum (Al3+) and organic carboxylate ligands. Notably, the prepared NH2-MIL-53­(Al) had no significant loss of adsorption performance even after being reused four times. All of these superior properties render the smart NH2-MIL-53­(Al) nanohexahedron a great potential for simultaneous Hg2+ detection and removal from water.

By rational in situ crystallization, HKUST-1 embedded in a chitosan film exhibits reduced cytotoxicity and restricted copper release, inducing enhanced infectious wound therapy.

This work describes an amorphous FeMn-MOF-74 adsorbent for the simultaneous removal and detoxication of As(iii) from aqueous solutions.

The selective adsorption by suitable substrate materials is considered one of the most economical methods. In this work, an all-inorganic bimetallic Mo-Fe-S cluster is facilely achieved through in situ chemical fixation of tetrathiomolybdate (TTM) on FeO nanoparticles (NPs) at room temperature (donated as FeMoS NPs). The bimetallic building blocks on the obtained FeMoS NPs possess a monovacancy species of sulfur, endowing FeMoS NPs with a selectivity order of Zn, Mn, Ni < Cd ≪ Cu < Pb for metal-ion adsorption, a novel application for the Mo-Fe-S clusters. Particularly, with the highest selectivity for Pb (K ≈ 10), which is about 3 × 10-1 × 10 times higher than those for other ions and has exceeded that of a series of outstanding sorbents reported for Pb, FeMoS NPs can efficiently reduce the concentration of Pb from ∼10 ppm to an extremely low level of ∼1 ppb. This facile and rational fabrication of the Mo-Fe-S cluster with FeO represents a feasible approach to cheaply develop novel and efficient materials for the selective removal of lead(II).