Copper metal–organic frameworks loaded on chitosan film for the efficient inhibition of bacteria and local infection therapy

Ren, Xinyi; Yang, Chengyuan; Zhang, Liang; Li, Sihang; Shi, Shuo; Wang, Rong; Zhang, Xu; Yue, Tianli; Sun, Jing; Wang, Jianlong

doi:10.1039/c9nr03612a

Cited by 117 publications

(55 citation statements)

References 54 publications

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“…Due to the slow release of copper ion and the presence of high contents of chitosan in these MOFs, an improved antibacterial activity against S. aureus and E. coli was achieved. Furthermore, novel MOFs based these multi-functional films effectively prevented S. aureus bacteria-derived wound infection (Figure 4) and enhanced the cutaneous wound repair without recurrence by stimulating the formation of blood vessels, epidermis and dermis (Ren et al, 2019).…”

Section: Surface Engineered Mofs In Multi-functional Dressings For Efmentioning

confidence: 99%

“…Various other factors, such as malnutrition, obesity, diabetes, medication, and lifestyle deregulate the process of wound healing by extending or stopping incidents in any phase of wound healing (Anderson and Hamm, 2012). Also, bacterial infection and the slow separation of fibroblasts may hinder the healing process, contributing to swelling, local pains, and even thus threatening complications (Lai and Rogach, 2017;Ren et al, 2019). Thus, there is a critical need to build alternative solutions to address unmet health challenges involved in wound care management (Nethi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…These technologies can address the complexity of the wounds and their specificity. Such nanotechnologies include the use of numerous metal-dependent nanoparticles and metal-organic frameworks (MOFs) (Hamdan et al, 2017;Ren et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Recently surface engineered MOFs have attracted a greater scientific interest for wound healing due to their intrinsic biological properties and delivery and controlled release of therapeutic agents (Zhang M. et al, 2020;Zhang S. et al, 2020). Moreover, the concept of surface engineered MOFs systems with or without therapeutic agents is gaining increasing popularity for quick and cost-effective wound healing (Yu et al, 2018;Ren et al, 2019;Zhang M. et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.

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Section: Surface Engineered Mofs In Multi-functional Dressings For Efmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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“…Aer 24 h, an aliquot (0.5 mL) was obtained, and the absorbance was measured at 600 nm using an ultraviolet spectrophotometer. 30…”

Section: Antibacterial Experiments With Different Materialsmentioning

confidence: 99%

An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

et al. 2020

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CelluMOFs: Green, Facile, and Flexible Metal‐Organic Frameworks for Versatile Applications

Zhang

Chen

et al. 2021

Adv Funct Materials

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Natural cellulose fiber-based materials have been widely used in daily life for a broad application owing to their intrinsic merits such as easy availability, eco-friendly, good processability, and outstanding physical-mechanical properties. Surface modification of natural fibers with nanostructures is an effective strategy to integrate the textile substrates with many favorable functionalities. Here, a green, facile, and universal method is introduced for the in situ growth of γ-cyclodextrin (γ-CD) metal-organic frameworks (MOFs) in cellulose fiber-based materials (CelluMOFs). Compared to the pristine fibers, the resulting CelluMOFs have high porosity with up to 50 times larger specific surface area and enhanced loading capacity to functional molecules (essential oils, antibacterial agents, and active drugs) with 23-36 times higher loading content. The CelluMOFs also exhibit high adsorption capability to volatile organic compounds and carbon dioxide. Moreover, the CelluMOFs textiles loaded with a model drug (doxorubicin) show a steady release profile and deep skin permeation capability. These CelluMOFs combine the advantages of both cellulose fibers and CD-MOFs, which greatly extend their applications in the fragrance industry, antimicrobial, pollutant removal, and biomedical textiles.

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Copper metal–organic frameworks loaded on chitosan film for the efficient inhibition of bacteria and local infection therapy

Abstract: By rational in situ crystallization, HKUST-1 embedded in a chitosan film exhibits reduced cytotoxicity and restricted copper release, inducing enhanced infectious wound therapy.

Cited by 117 publications

References 54 publications

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

CelluMOFs: Green, Facile, and Flexible Metal‐Organic Frameworks for Versatile Applications

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