Objectives: Convalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management of viral diseases. We investigated its effectiveness for the treatment of COVID-19. Design: Open-label, parallel-arm, phase II, multicentre, randomized controlled trial. Setting: Thirty-nine public and private hospitals across India. Participants: Hospitalized, moderately ill confirmed COVID-19 patients (PaO2/FiO2: 200-300 or respiratory rate > 24/min and SpO2 ≤ 93% on room air). Intervention: Participants were randomized to either control (best standard of care (BSC)) or intervention (CP + BSC) arm. Two doses of 200 mL CP was transfused 24 hours apart in the intervention arm. Main Outcome Measure: Composite of progression to severe disease (PaO2/FiO2<100) or all-cause mortality at 28 days post-enrolment. Results: Between 22 nd April to 14 th July 2020, 464 participants were enrolled; 235 and 229 in intervention and control arm, respectively. Composite primary outcome was achieved in 44 (18.7%) participants in the intervention arm and 41 (17.9%) in the control arm [aOR: 1.09; 95% CI: 0.67, 1.77]. Mortality was documented in 34 (13.6%) and 31 (14.6%) participants in intervention and control arm, respectively [aOR) 1.06 95% CI: -0.61 to 1.83]. Interpretation: CP was not associated with reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates real-life setting of CP therapy in settings with limited laboratory capacity. A priori measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in management of COVID-19.

Background: Dengue viral infections are the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public concern. Objective: To evaluate hematological changes in serologically proven patients with clinical manifestations of dengue fever at tertiary care hospital. Materials and Methods: Cases of fever, clinically suspected to be dengue were confirmed by immunochromatographic tests for dengue NS1 antigen and dengue IgM antibody during the period from September 2015 to November 2015. A total of 250 seropositive dengue cases were correlated with clinical features, hematological, and biochemical findings. Result: With the most common clinical feature-high grade fever (95%), the main hematological findings were raised hematocrit (>29%), leukopenia (44%), and thrombocytopenia (59%). Conclusion: Hemoconcentration, leukopenia, thrombocytopenia, raised SGPT, and raised serum bilirubin gave enough clues to test for dengue serology so as to reduce the morbidity and mortality because of this disease.

Background: Both macroscopic and microscopic appearance helps in identification of the colon lesion which supports in the treatment of the patient in a better way. The authors were aimed at the prevalence of various colon lesions site wise distribution of various neoplastic and non-neoplastic lesions of the patients and to compare the distribution according to their age, sex and site.Methods: A retrospective study was designed to study of various intestinal biopsies sent for histopathological examination at Department of Pathology, N.H.L. Municipal Medical College and V.S. Hospital, Ahmedabad, from January 2015 to December 2016 for period of 2 years. The study was based on the histomorphological evaluation of colon lesions received during the study period.Results: A male preponderance was seen in the incidence of tumors irrespective of tumor type and site of tumor and M:F ratio was 1.64:1. In the large intestine, adenocarcinomas were the commonest malignant tumor. 46 cases (62.61%) were reported. The highest occurrence of appendicitis is in the 2nd and 3rd decade.Conclusions: The study revealed that various types of lesions in large intestine along with the age group and gender affected more. Male patients were majorly affected. Morphological identification helped to diagnose the type of lesion for early diagnosis. This study focuses the role of histopathological identification in early diagnosis of the disease so that the survival rates in such cases will be increased.

Introduction: Anemia is a common health problem in overall world especially in developing countries. Early and accurate diagnosis is needed to decide correct line of treatment. Material & Methods: The study was conducted in Hematology laboratory of medical college hospital for a period of 12 month during January 2018 to December 2018. Total 1500 anemic patients of 10-70 year of age were included in the study. Interpretation of RBC Histogram and peripheral smear examination was done in each case. Results: Out of total 1500 anemic cases, microcytic anemia is most common cause followed by normocytic, Dimorphic and macrocytic anemia. Female patients are more than male patients and most common involved age group is 31-40 years followed by 21-30 years. Discussion: Interpretation of RBC histograms is useful method for initial diagnosis of anemia and can be used for screening purpose to screen large population.

Background: Malaria is a major health problem in many parts of India. Several factors have beenattributed to increased morbidity and mortality in malaria with altered hematological andcoagulation parameters. This study was conducted to compare the coagulation parameters ofmalaria cases with those of the healthy carriers. Aims and objectives: To evaluate coagulationabnormalities in patients of malaria and to study the difference in coagulation parameters betweenmalaria patients and healthy controls and to determine the level of significance of the difference.Materials and methodology: This prospective comparative study of 300 patients with laboratorydiagnosed malaria patients (cases) and 300 healthy individuals (controls) was carried out in theDepartment of Pathology in a tertiary care, V. S. General Hospital, Ahmedabad. Result: Comparisonof platelet count, PT, and aPTT between case groups and control groups was statistically significant(p<0.001). Conclusion: There is a significant difference between the platelet count, PT, and aPTTvalues of the two groups. This indicates that in patients with malaria, there is an activation ofintrinsic and extrinsic pathways of coagulation.