This study aims to research the effects of the ownership of ICT on hospital performance in the Cameroonian context. To achieve this objective, data from a field survey of a valid random sample of 479 employees from first and second category hospitals in Cameroon are subjected to descriptive and econometric analyzes. The results obtained reveal that the level of ownership of ICT by hospital staff is very average and has an impact on hospital performance. Indeed, the inferential analyzes performed using simple regression showed a positive and significant effect of the perceived ease of use of ICT, the perceived usefulness and cognitive absorption on hospital performance. These results, discussed from the perspective of Berbain and Minvielle (2001), Li, Benton and Leong (2002), Mukuna (2016 and Picard (2007) suggest acting on the determinants of ICT ownership, which are: training, raising awareness and improving the working conditions of hospital staff if we want to improve their ability to use and their enthusiasm for this use of ICT. this would improve staff satisfaction, patient satisfaction and the quality of clinical services.