Background: Cancer is abnormal growth of cells, which invade or spread to other parts of the body. There are over 200 types of cancers. Breast cancer is a cancer which develops in tissues of the breast, most commonly originating from the inner lining of milk ducts or lobules that supply ducts with milk. Tecoma stans commonly known as trumpet flower is a yellow trumpet shaped flower belonging to Bignoniaceae, and is native to Americas. It has anti cancer and anti proliferative properties. Aim: Aim of the is to analyse the anti cancer activity of Tecoma stans against breast cancer cells MCF-7. Materials and Methods: Breast cancer cell line (MCF-7) was purchased from National Centre for Cell Sciences (NCCS), Pune, India. Cell viability test was done by MTT assay. BcL2 and BclxL gene expression analysis was done by Real Time-PCR. The obtained data were analysed statistically by one-way analysis of variance and Duncan’s multiple range test with Graph Pad Prism version 5 to analyse the significance. The significance was considered at p<0.05 level in Duncan’s test. Results: The results suggest Bcl2 mRNA gene expression is reduced on induction of 400, 500 ug/ml of Tecoma stans with significant difference in comparison with control. Bcl-xL mRNA gene expression is slightly reduced on induction of 400, 500 μg/mL of Tecoma stans with no significant difference in comparison with control. Conclusion:  From the obtained results, it can be concluded that hydroethanolic leaf extract of Tecoma stans possess anticancer activity against breast cancer cells with respect to Bcl2 mRNA gene expression as compared to Bcl xL mRNA gene expression. If complete research is done, we can use this drug to treat various cancers.

It is of interest to analyse and compare the antioxidant and anti-diabetic activity of ethanolic extracts of Andrographis echioides and Andrographis paniculata. Andrographis echioides and Andrographis paniculata were collected from a local farm. In vitro antioxidant activity was assessed by the potential of Piperine, Lupeol, beta sitosterol; DPPH free radical scavenging assay was performed by Liyana Pathirana and Shahidi method. In vitro anti-diabetic activity was assessed by alpha amylase inhibitory activity and alpha glucosidase inhibitory activity. The data were analysed by one-way-ANOVA to check the statistical significance among the groups and considered at the levels of p<0.05. Both the ethanolic extracts of Andrographis echioides and Andrographis paniculata showed significant antioxidant and anti-diabetic potential in a dose-dependent manner (100-500μg) and can be used as potential antidiabetic agents. Similar to antioxidant potential, Andrographis paniculata exhibited an increased anti-diabetic potential compared to Andrographis echioides. Data shows that the ethanolic extracts of Andrographis echioides and Andrographis paniculata possessed antioxidant and anti-diabetic activity and hence our present findings conclude that both plants can be considered for the development of natural drugs for the management of diabetes.

Introduction: A condition in which the body’s ability gets impaired to process blood glucose level is called diabetes, otherwise known as blood sugar. It ranked sixteenth among leading causes of death around the globe. There are estimated 72.96 million cases diagnosed with diabetes in the adult population of India. Momordica charantia possess anti-diabetic, anti hyperglycemic and anti inflammatory properties. Mangifera indica is traditionally used to treat diarrhoea, cancer, diabetes and tooth aches. Aim: Aim of this study is to analyse comparative evaluation of anti-diabetic potential of aqueous seed extracts of Momordica charantia, seed kernel extract of Mangifera indica through in vitro analysis. Methods: Momordica charantia and Mangifera indica were collected from local farms, and the extracts were analysed for its phytochemicals. Antioxidant and Anti-diabetic potential of the seed extract were evaluated along with standards. The data were analysed statistically by a one way analysis of variance (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant. Results: Momordica charantia and Mangifera indica and its herbal formulation showed significant antioxidant and anti-diabetic potential. Conclusion: The results showed both the seed and seed kernel extracts of Momordica charantia and Mangifera indica possessed anti-diabetic activity but the herbal formulation possessed much more significant anti-diabetic activity than the individual extract.