Alzheimer's disease (AD) is the most common form of dementia with a progressive course. AD pathology is a manifestation of the underlying severity and neuroanatomic involvement of specific vulnerable brain regions and circuits that are responsible for neuronal dysfunction and death. The etiology of AD is largely unknown. It has been hypothesized that multiple factors, including genetic components, oxidative stress, intracellular or extracellular accumulation of amyloid, dysfunction of cystoskeletal and synapse components, neuronal loss by apoptosis, neuronal excitotoxicity, inflammation, mitochondria dysfunction, etc., may play important roles in the onset of the disease. WWOX/WOX1 is a candidate tumor suppressor. Human WWOX gene, encoding the WW domain-containing oxidoreductase (designated WWOX, FOR, or WOX1) protein, has been mapped to a fragile site on the chromosome ch16q23.3-24.1. Functionally, the WW domain is not only a tumor suppressor, but also a participant in molecular interactions, signaling, and apoptosis in many diseases. In this article, we review the potential mechanism by which WWOX/WOX1 may participate in the pathogenesis of AD with a focus on cell death signaling pathways in neurons.

We perform femtosecond degenerate pump-probe experiments on an InGaN thin film of 800 nm in thickness. The observed temperature-, pump-photon-energy-, and pump-intensity-dependent variations of ultrafast carrier dynamics manifest the variation of the space-averaged density of state with energy level in this sample. The carrier dynamics is controlled by the shift of effective band gap and hence the behavior of band filling, which are determined by the combined effect of band-gap renormalization and phonon effect (band-gap shrinkage with increasing temperature). Two-photon absorption and free-carrier absorption can be observed when the corresponding density of state is low and hence the band-filling effect is weak. The variation of the space-averaged density of state with energy level can be due to the existence of indium-composition-fluctuation nanostructures, which is caused by the spinodal decomposition process, in the sample.

Recent developments in video content analysis contribute to the emergence of multimedia database management. With the rapid growth of digital videos, efficient tools are essential to facilitate content indexing, searching, retrieving, browsing, skimming, and summarization. Sport video analysis has attracted lots of research attention because of its entertainment applications and potential commercial benefits. Sport video analysis aims to identify what excites audiences. Previous methods rely mainly on video decomposition, using domain specific knowledge. Research on suitable and efficient techniques for sport video analysis has been conducted extensively over the last decade. However, several longstanding challenges, such as semantic gap and commercial detection, are still waiting to be resolved. This chapter reviews research on sport video analysis and investigates the potential applications and future trends of sport video analysis.