Background: Hyperuricemia is an abnormally high level of uric acid in the blood. Ginger and lime are natural ingredients that contain antioxidants and anti-inflammatory which could reduce blood uric acid levels. This study aims to prove the effect of red ginger powder and lime juice combination on uric acid levels of Wistar rats induced hyperuricemia.Methods: Experimental research with pre and post-test only control group design. Thirty Wistar male rats, aged 2-3 months, weighed 150-350 grams randomly divided into 5 groups. Group C1 was normal control group. Group C2 was induced by single intraperitoneal injection of potassium oxonate (300mg/kgBW). Group T1, T2, T3 were induced by potassium oxonate and orally administered by combination of red ginger powder (300, 600, 1200 mg/200gBW) and lime juice (2ml/150gBW). Blood samples in each group will be collected in 1 hour after treatment. Uric acid levels were measured using the TBHBA uric acid method.Results: Uric acid level in T1, T2, and T3 group was significantly lower than C2 group (p<0,05). The most effective dose to reduce uric acid levels was 1200mg/200gBW red ginger in combination with 2ml/150gBW lime juice (T3 group).Conclusion: Red ginger powder and lime juice may reduce the blood uric acid levels in Wistar rats induced hyperuricemia.

Background: Reaction time is a cognitive-motoric connection that is important in making quick decisions. Due to the lack of time, medical student has low physical activity.  High Intensity Interval Training (HIIT) is a strong and intense exercise interspersed with low intensity exercise that does not require much time. It has been known that can improve cognitive function.Objective: To determine the effect of HIIT on an individual’s reaction time.Methods: Quasi-experimental research with pre-test and post-test groups design. The research subjects were 29 medical students of Diponegoro University, woman, normal IMT, 18-22 ages, has no neurologic deficit. The control group instructed not to do any physical exercises (n=15) and the experimental group was given an intervention of HIIT exercises that consists of warm-up, core, and cool-down movements for 6 weeks (n=14). Reaction time scores before and after were measured using the Attention Network Test (ANT). The significance of the data was analyzed using the paired sample t-test the independent sample t-test.Results: A significant decrease in reaction time scores (p=0,007) in both the experimental and control groups. A significant difference in reaction time scores (p=0.007) between the experimental group before and after the intervention was 592,07±74,82 to 517,21±56,77 milisecond. A significant difference in reaction time scores (p=0.024) between the control group before and after the intervention was 611,73±78,93 to 574,06±47,06 milisecond.Conclusion: HIIT for 6 weeks has been proved to reduce reaction time scores.  Keywords: High Intensity Interval Training, Physical Exercise, Reaction Time, Attention Network Test.