For the bidirectional wireless power transfer system of electric vehicles, the topology proposed in this paper includes a direct three-phase AC–AC matrix converter as the pre-stage main circuit, a bilateral inductor–capacitor–capacitor–inductor (LCCL) as the resonance compensation network, and a full-bridge converter as the latter stage circuit. According to the characteristics of the system topology, a new control strategy is proposed based on the de-re-coupling method. The control principle of the coordination work of the scheme is expounded, and the corresponding switch combination logic is designed. According to the three-phase voltage amplitude relationship at different stages, combined with the resonant frequency, the switch arms of the matrix converter are alternately controlled separately. The number of switching operations is reduced, the system efficiency and safety are improved, and the full range of soft switching operations of the converter is realized. The theoretical analysis of the bilateral LCCL resonance compensation network is carried out, and its constant voltage/current output characteristic and high power factor transmission characteristic are obtained. Finally, the effectiveness and feasibility of the bidirectional wireless power transfer system for electric vehicles proposed in this paper are verified by simulation analysis.
On account of that nine-switch inverter (NSI) cannot supply symmetrical voltages to unbalanced loads, based on the NSI, N-phase leg is added to the neutral points of the loads, which forms a four-leg nine-switch inverter (FLNSI). The neutral point voltages under unbalanced loads are analysed and derived by space vector pulse width modulation (SVPWM) strategy for calculating the duty ratio of N-phase leg. While the calculations of other three-phase legs duty ratios of SVPWM method remain unchanged. Although SVPWM method can realize FLNSI outputs symmetrical voltages for unbalanced loads, it needs trigonometric function calculation and sector judgements. The carrier-based pulse width modulation (CBPWM) strategy is proposed for the sake of simplifying SVPWM. All of the duty ratios are used to calculate modulation waves of FLNSI. Compare the modulation waves with a carrier, which can control the neutral point voltages as corresponding zero-sequence voltages. Therefore, two groups of three-phase symmetrical sinusoidal voltages are obtained under both balanced loads and unbalanced loads. Finally, the experimental results are given to show the advantages of FLNSI topology and to validate of the effectiveness of the applied modulation strategy. INDEX TERMS Carrier-based pulse width modulation (CBPWM), four-leg nine-switch inverter (FLNSI), space vector pulse width modulation (SVPWM), unbalanced loads.
The transcriptional profile of PC-3 human prostate cancer cells infected with tumor-targeting Salmonella typhimurium A1-R (A1-R) was analyzed with by microarray. PC-3 is highly sensitive to A1-R. Numerous genes involved in diverse cellular processes, including apoptosis, necrotic cell death, neutrophil chemotaxis and innate immunity were significantly up-regulated by A1-R bacterial infection. Such up-regulated genes include TNF-a, Fos and JUN which are involved in cell death and IL-1A and CXCL which are involved in neutrophil chemotaxes. Knowledge of the up-regulated gene profile will be exploited for enhancing prostate tumor targeting by A1-R.
Keywords: Salmonella typhimurium A1-R, human prostate cancer, microarray, apoptosis, necrotic cell death, neutrophil chemotaxis, tumor-targeting.
Citation Format: Ming Zhao, Wen Wu, Chongyi Lu, Yong Zhang, Robert M. Hoffman, Hui Qi, Meng Yang, Yanqin Gu, Yiyu Lu, Shibing Su, Hui Zhang, Qianmei Zhou, Qilong Chen. Microarray gene expression analysis of human prostate cancer PC-3 cells targeted by Salmonella typhimurium A1-R. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4903. doi:10.1158/1538-7445.AM2015-4903
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