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The contribution of cholinergic dysfunction to the non-mnestic cognitive impairments associated with senile dementia of the Alzheimer type (SDAT) was investigated. Scopolamine (0 . 5 mg) was administered intravenously to 12 healthy individuals, and their performance on selected subtests of the Wechsler Adult Intelligence Scale Ð Revised (WAIS-R), and on additional non-mnestic neuropsychological tests were compared to that of 12 healthy control participants. The results demonstrate that scopolamine does impair performance on components of the WAIS-R, but that the Fuld WAIS-R pro®le does not have a cholinergic basis. Scopolamine did not impair performance on verbal¯uency, the Token Test, Judgment of Line Orientation, ®nger tapping, the Modi®ed Card Sorting Test, or the Mini-Mental State Examination. The results do not support the hypothesis that the cholinergic system contributes to the non-mnestic impairments in SDAT. #

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