Purpose Many survivors of breast cancer experience an array of chronic symptoms, including pain, insomnia, and fatigue. Few effective therapies have been identified. Behavioral management programs to address similar symptom clusters in other chronic conditions have been effective. The objective of this study was to determine the effect of an Internet-based lifestyle and behavioral self-management program on cancer-related symptoms. Patients and Methods Women with stage 0 to 3 breast cancer who reported insomnia, pain, or fatigue as their primary symptom of concern during the 7 days before enrollment were enrolled. Local therapies and/or chemotherapy were completed at least 3 months before enrollment. Patients were assessed at baseline and after 8 weeks, and they completed the Patient-Reported Outcomes Measurement Information System (PROMIS)–29 Profile and Patient Global Impression of Change (PGIC) questionnaire electronically. Change in each of the eight symptom domains was assessed. Results Fifty patients enrolled. In the 45 patients with both baseline and 8-week PROMIS data, statistically significant improvements in anxiety, sleep, fatigue, activity level, and pain severity were reported. Of the 35 patients who responded to the PGIC, 62.9% reported improvement in their primary symptom. Those who reported fatigue as their primary symptom reported greatest overall benefit in multiple symptom improvement, including improvements in fatigue, anxiety, pain severity, pain interference, and participation in social activities. Conclusions These findings suggest that this lifestyle and behavioral management program may improve multiple symptoms in breast cancer survivors when delivered via the Internet. Randomized studies are warranted to evaluate the efficacy of the online intervention compared with standard symptom management approaches and to identify patients most likely to benefit.

Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning and memory, and the FosB gene has been suggested to play a role in neuronal proliferation. However, the subregion-specific and potentially cell-autonomous role of dHPC ΔFosB in neurogenesis-dependent learning has not been studied. Here, we crossed neurotensin receptor-2 (NtsR2) Cre mice, which express Cre within the subgranular zone (SGZ) of dHPC DG, with floxed FosB mice to show that knockout of ΔFosB in hippocampal SGZ neurons reduces antidepressant-induced neurogenesis and impedes hippocampus-dependent learning in the novel object recognition task. Taken together, these data indicate that FosB gene expression in SGZ is necessary for both hippocampal neurogenesis and memory formation.

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This exploratory study investigates intimate partner homicide (IPH) offenders’ criminal histories to examine opportunities for criminal justice system intervention. Data were collected from the Michigan Violent Death Reporting System and Michigan State Police for the 117 IPHs committed in 2014 and 2015 in Michigan. Descriptive statistics on types of criminal charges and convictions for the 103 IPHs committed by aggressors (e.g., not in self-defense) are presented, with relatively few domestic violence charges or convictions. Twenty-nine percent of offenders had no criminal history. Findings highlight a need for more effective and greater implementation of interventions for both criminal justice system-involved and not-involved offenders.

Fear of crime is a frequently cited reason individuals carry firearms. Mass shootings are particularly fear-inducing events, and for some incidents, media coverage inundates the public with details of these tragedies. This reporting may increase individuals’ fear of such incidents and, subsequently, may spur demand for handgun carrying permits (HCPs). Newspaper reports have documented changes in HCP application rates following high-profile mass shootings. We empirically assess this possible relationship using HCP application rates in all 95 counties in Tennessee from 2008 through 2014. Results suggest certain high-profile mass shootings are significantly associated with increased HCP application rates.