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The authors report a case of lightning maculopathy with serial spectral domain optical coherence tomographs that, for the first time, elegantly illustrate the natural history of this uncommon, ominous condition.

Refractive surgery is an option for children with amblyopia and strabismus who fail treatment with spectacles or contact lenses. Prospective controlled studies are needed, and longer follow-up will answer questions about the utility and safety of refractive surgery in children.

Our objective is to evaluate the literature regarding selected genetic diseases of the cornea, including megalocornea, keratoglobus, keratoconus, cystinosis, the mucopolysaccharidoses, sclerocornea, Peters' anomaly, familial dysautonomia, and various corneal dystrophies. The transparency of the cornea is a consequence of uniformity in both size and spacing of the collagen lamellae. The cornea's clarity depends on a delicate biochemical and structural balance; consequently, genetic disorders that disrupt either its metabolic or anatomic function can cause opacity and vision loss. Many childhood corneal diseases have a genetic etiology and are associated with known syndromes. Each disorder has unique associated set of possible complications. Prognosis often depends on the extent of opacity and disorganization of the anterior segment. Corneal transplantation has been performed for these disorders with variable success.