Prostate cancer (PCa), which is an aggressive malignancy of the male genitourinary system. In the present study, the effects of microRNA‐140 (miR‐140) on PCa were determined. We transfected miR‐140 mimics or negative control into PCa cells, and we used MTT, wound healing, and Transwell assays for determining the capacities of miR‐140 in cell proliferation, migration, and invasion, respectively. We also confirmed the relationship between miR‐140 and YES proto‐oncogene 1 (YES1) using Luciferase reporter assay. The results showed that miR‐140 was downregulated in PCa cells and tissues, and overexpression of miR‐140 could significantly suppress their capacities of proliferation, migration, and invasion. Moreover, YES1 was shown to be a direct target of miR‐140. Moreover, miR‐140 expression is negatively correlated with YES1 levels. miR‐140 exhibits significant tumor‐suppressive effects in PCa by inhibiting YES1. The study indicated that miR‐140 and YES1 could be the potential targets for PCa therapy.
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