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Background: Anambra state in south-east Nigeria is one of the high TB burden states in the country. Despite recent improvements in TB case notification, estimates from the National Prevalence survey suggest that there is still a significant pool of missed TB cases in the state. Although active TB case finding interventions are needed at community level, information on local TB transmission hotspots is lacking. The objective of this study was to map the geo-spatial location of all TB cases detected in the state in 2019. Findings from this secondary data analysis will help to target interventions appropriately with a view to achieving better program efficiency. Method: A de-identified dataset containing descriptive physical addresses of registered TB cases in 2019 was developed. The dataset was then deconstructed and restructured using Structured Query Language in a relational data base environment. The validated dataset was geocoded using ArcGIS server geocode service and validated using python geocoding toolbox, and Google geocoding API. The resultant geocoded dataset was subjected to geo-spatial analysis and the magnitude-per-unit area of the TB cases was calculated using the Kernel Density function. TB case notification rates were also calculated and Choropleth maps were plotted to portray the TB burden as contained in the dataset. Results: Five local government areas (LGAs) (Onitsha North, Onitsha South, Idemili North, Nnewi North, Ogbaru) had spots with "Extremely high" burden with two LGAs (Onitsha North and South) accounting for the largest spots. EightLGAs had spots with "Very high" TB burden. Also, 24 hotspots across the How to cite this paper: Ugwu, C.I.,