This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC-MSCs) for the treatment of osteonecrosis of the femoral head (ONFH). The biological characteristics of hUC-MSCs were assessed using flow cytometry. Nine eligible patients were enrolled in the study as they adhered to the Association Research Circulation Osseous (ARCO) classification of stage II–IIIa, and hUC-MSCs were grafted by intra-arterial infusion. Organize effective perfusion was assessed using the oxygen delivery index (ODI). The results showed that the ODI was increased at three days post-operation. The MRI results revealed that at 12 and 24 months after treatment, the necrotic volume of the femoral heads was significantly reduced. No obvious abnormalities were observed. Taken together, these data indicate that intra-arterially infused hUC-MSCs migrate into the necrotic field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads. This finding suggested that intra-arterial infusion of hUC-MSCs MSCs is a feasible and relatively safe method for the treatment of femoral head necrosis.

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Based on the Kronig–Penney model, the changing tendency of the bandgap or of a particular level with the volume deformation in crystalline materials has been derived. On the basis of this changing tendency, the zero-phonon charge transfer (CT) energy is deduced to be decreased when the size of Y2O3:Eu3+ phosphor decreases into the nanoscale. In addition, the rigidity decrease of the lattice environment in Y2O3:Eu3+ nanophosphor leads to the enlargement of the CT state coordinate offset of the optical centers; this means that an optical center would reach a higher vibration level in CT excitation. The increasing magnitude of the vibration energy is smaller than the decreasing magnitude of the zero-phonon CT energy when the size of the Y2O3:Eu3+ phosphor decreases into the nanoscale. As a result, the CT energy is decreased, and the CT excitation spectrum shifts to a lower energy.