Control of microorganisms is vital to prevent infection. Prevention can be done in various ways, one of which is the use of disinfectants and antiseptics. The widespread use of disinfectants and antiseptics due to the outbreak of COVID-19 has led to the use of antiseptics that are not appropriate for society. The use of biocide agents that are not used correctly can endanger the health of its users. It is recommended that pharmacists, related health workers, and the public should learn more comprehensively about the use of disinfectants and antiseptics when a pandemic occurs. This review is done by searching Google Scholar as a database. This article discusses biocide agents, especially disinfectants and antiseptics, including definitions, ingredients and concentrations, antimicrobial effectiveness, factors affecting disinfection, hazards, techniques, and accuracy of the dosage of their use, the use and advantages and disadvantages of several classes of disinfectants and antiseptics that must be understood to be useful in their use, in this review also describe some formulations of disinfectant and antiseptic products circulating in the community that can be obtained and used from the commercial market.