Despite its importance in guiding public health decisions, studies on COVID-19 vaccination acceptance and its determinants in South East Asia (SEA) are lacking. Therefore, this study aims to determine the prevalence of COVID-19 vaccine acceptance and the variables influencing the vaccine’s acceptance. This review is registered under PROSPERO CRD42022352198. We included studies that reported vaccination acceptance from all SEA countries, utilising five academic databases (Pubmed, MEDLINE, Cochrane Library, Science Direct, and Google Scholar), three Indonesian databases (the Indonesian Scientific Journal Database, Neliti, and Indonesia One Search), two pre-print databases (MedRxiv and BioRxiv), and two Thailand databases (ThaiJo and Thai-Journal Citation Index). The analysis was conducted using STATA 17.0 with metaprop commands. The prevalence for COVID-19 vaccination acceptance in SEA was 71% (95%CI 69–74; I2 99.87%, PI: 68.6–73.5). Myanmar achieved the highest COVID-19 vaccination acceptance prevalence, with 86% (95%CI 84–89), followed by Vietnam with 82% (95% CI 79–85; I2 99.04%) and Malaysia with 78% (95%CI 72–84; I2 99.88%). None of the ten determinants studied (age, sex, education, previous COVID-19 infections, smoking and marriage status, health insurance, living together, chronic diseases, and healthcare workers) were significantly associated with acceptance. This result will be useful in guiding vaccination uptake in SEA.

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Background: Breast cancer is the most common type of cancer amongst female in Indonesia. Among other therapies, chemotherapy is believed as the primary solution for Cancer. However, some reports stated the declining on individual function after chemotherapy. The aim of this study is to find out the increasing dependency due to chemotherapy. Methods: The study was a cross-sectional, consecutive and randomized sampling study using Instrumental Activities of Daily Living questionnaire which focused on individual dependency to spot progression or regression over time. Cut off point of 6 indicates independence or dependence of an individual. Data was collected at January 2018 at our general hospital by asking the questions twice (before and after chemotherapy). Chi Square method was used to define the relationship between dependency and chemotherapy. Results: There were 22 breast cancer patients with median of age 49 (32 -65) with average of 5 chemotherapy were done, excluding their chronic diseases. Relations between dependency before and after chemotherapy was statistically significant with p val-ue¼0.000. Patients who were independent and still independent now were 11 over 19 (57.89%), patients who were independent then and dependent now were 8 over 19 (42.10%) and 3 patients were dependent even before they started chemotherapy. Of all deteriorating aspects, shopping had the most significant decline. Conclusion: There were relations between chemotherapy with a decline in patients independence. However, further study with greater sample is needed to confirm the results.P3 À 186 Risk of sarcopenia as the side effect of chemotherapy among breast cancer patients: preliminary study

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Febrile seizure (FS) is the most common convulsive disorder in children with FS prevalence in Indonesia reaching 2 to 4% in 2008. Although this entity has a good prognosis, it often brings panic, fear, and anxiety to the parents. This seemingly benign condition might lead to changes in family structures resulting in adverse effects on the family's daily lives and affect their overall quality of life (QoL). This study evaluates the QoL of parents whose children have FS. A cross-sectional study done in 47 parents whose children had a FS between ages 1 and 4 years from January 2020 to May 2020 and who were evaluated at the Siloam General Hospital, Lippo Village. Parents were asked to fill in Pediatric Quality of Life Questionnaire parent proxy. Data normality was analyzed using the Shapiro–Wilk's test and the significant impact of parents' QoL using the chi-square and independent t-tests. From a total of 47 parents, 30 (63.8%) parents had children with simple FS and 17 (36.2%) parents had children with complex FS. Parents whose children were in the age group of 1 year to 1 year 11 months had the best mean score of 79.64 (12.17) compared with other age groups. In the subset of 3 to 4 years old, the daily activities domain was significantly affected (p-value = 0.3). Parents with a lower educational level had a higher mean score of 76.53 (14.42) than parents who had a higher educational level, with a total mean of 79.88 (11.85), particularly with the highest mean score of 100 in the communication domain. The occurrence of FSs in children affected their parents' QoL in almost all domains in the Pediatric Quality of Life Inventory questionnaire.