Toxicity testing of natural ingredients used in raw materials for making herbal medicines needs to be done to ensure its safety. In general, toxicity tests are divided into 2 types namely general toxicity and specific toxicity. One specific toxicity test is the teratogenic test. Teratogenic testing is part of a special toxicity test that is intended to determine the toxic effect of a compound on the fetus or fetus. The writing of this journal aims to explain the teratogenic toxicity testing technique by referring to the Organization for Economic Co-operation and Development (OECD) 414 and OECD 236 on herbal medicines. Some examples of herbs used for testing teratogenic toxicity as studied by Lu E. The et al. On Bougainvillea glabra (Paper Flower) with the results of a study of water extracts in purple and dark pink, B. glabra bract is not toxic to embryos, except the pink type with LC 50 85.51 ?g / mL. then there is Mindi leaf (Melia azedarach L) which was investigated by Adisti erlina sutomo et al with the results of extracting at a dose of 3.22 mg / kg bw already causing teratogenic toxicity. And there are still some herbs that are used for teratogenic toxicity testing with mixed results.