The Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends (PROSPECT) is a prospective cohort study in Puerto Rico (PR) aiming to identify trends and longitudinal associations in risk factors for cardiovascular disease (CVD). In 2019, PROSPECT started recruiting a sample of 2,000 adults, ages 30-75 years, in PR using a multi-stage probabilistic sampling of households and community approaches. Culturally-sensitive trained research assistants assess participants, at baseline and at 2-year follow-up, in private rooms in a network of partner clinics. The study collects comprehensive data on demographics, socioeconomic and environmental factors, medical history, health conditions, lifestyle behaviors, psychosocial status, and biomarkers of CVD and stress. PROSPECT will estimate the prevalence and incidence of psychosocial, lifestyle, and biological CVD risk factors, describe variations in risk factors by urban versus rural area and after natural disasters, and determine predictors of longitudinal changes in CVD risk factors. The study has four coordinated operational strategies: (1) research productivity (including synergy with existing epidemiological cohorts of Hispanics/Latinos for comparison); (2) research infrastructure (biorepository, ancillary studies, and clinical research network); (3) capacity-building, education, and training; and (4) community outreach, dissemination, and policy. PROSPECT will inform public health priorities to help reduce CVD in PR.

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