IMPORTANCE Identifying health care settings and professionals at increased risk of SARS-CoV-2 infection is crucial to defining appropriate strategies, resource allocation, and protocols to protect health care workers (HCWs) and patients. Moreover, such information is crucial to decrease the risk that HCWs and health care facilities become amplifiers for SARS-CoV-2 transmission in the community. OBJECTIVE To assess the association of different health care professional categories and operational units, including in-hospital wards, outpatient facilities, and territorial care departments, with seroprevalence and odds of SARS-CoV-2 infection. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was conducted using IgG serological tests collected from April 1 through May 26, 2020, in the Lombardy region in Italy. Voluntary serological screening was offered to all clinical and nonclinical staff providing any health care services or support to health care services in the region. Data were analyzed from June 2020 through April 2021. EXPOSURES Employment in the health care sector. MAIN OUTCOMES AND MEASURES Seroprevalence of positive IgG antibody tests for SARS-CoV-2 was collected, and odds ratios of experiencing infection were calculated. RESULTS A total of 140 782 professionals employed in the health sector were invited to participate in IgG serological screening, among whom 82 961 individuals (59.0% response rate) were tested for SARS-CoV-2 antibodies, with median (interquartile range [IQR]; range) age, 50 (40-56; 19-83) years and 59 839 (72.1%) women. Among these individuals, 10 115 HCWs (12.2%; 95% CI, 12.0%-12.4%) had positive results (median [IQR; range] age, 50 [39-55; 20-80] years; 7298 [72.2%] women).

Combining these results with those obtained in other MONICA centres, it appears that further decreases in coronary mortality might be achieved through specific programmes addressed in particular to the reduction of out-of-hospital case-fatality in lower social classes.

O ensino dos estudos sociais nos anos iniciais do ensino fundamental é a temática deste texto. Por que ensinamos estudos sociais nos anos iniciais da educação básica da forma como ensinamos? Que concepção epistemológica e pedagógica orienta essa forma de organização do currículo escolar dos Estudos Sociais? Como se produziu o ensino dos estudos sociais que toma como referência os círculos concêntricos? O objetivo é fustigar a tradição consolidada em torno da forma como ensinamos os conhecimentos dos Estudos Sociais nos anos iniciais do ensino fundamental da educação básica. É uma reflexão com caráter ensaístico permeado pelos anos de experiência de ensino nos anos iniciais e da formação inicial e continuada de professores. Antecipa-se que a disposição curricular dos conteúdos dos estudos sociais nos anos iniciais está organizada tomando como referência os pressupostos epistêmicos dos círculos concêntricos, ou seja, do próximo e imediato para o mais distante e abstrato ou do mais simples para o mais complexo.

Introduction/Background Anal high-grade intraepithelial neoplasia (AIN2-3) is the precursor of HPV-related anal cancer. Although anal cancer is rare, its incidence is rising, especially in women. Women with high-grade cervical neoplasia (CIN2-3) or HPV-related genital cancer are at increased risk of developing AIN. Other risk groups include people living with HIV, immunocompromised patients, and Men who have Sex with Men (MSM).

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