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Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life-threatening, yet noninvasively differentiating NASH from simple steatosis is challenging. Herein, bifunctional probes have been developed that target the hepatocyte-specific asialoglycoprotein receptor (ASGPR), the expression of which decreases during NASH progression. The results show that the probes allow longitudinal, noninvasive monitoring of ASGPR levels by positron emission tomography in the newly developed rat model of NASH. The probes open new possibilities for research into early diagnosis of NASH and development of drugs to slow or reverse its progression.

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Studies on the chromoprotein antibiotic neocarzinostatinThe ‘special effects’ of microwaving in radiochemistry.Stable isotopes and membrane transport proteins: chemical synthesis and biochemical analysis by solid state NMRSynthetic aspects of c‐deuteriation of enolatesOpportunities for isotope labelling via solid phase synthesis with organogermanium linkersLabelled methyllycaconitine (MLA)—a key nicotinic acetylcholine receptor ligandChallenges in the preparation of radiolabelled drugs for nuclear medicineThe synthesis of carbon‐14 labelled PEGsDevelopment of palladium catalysed carbonylations for asymmetric synthesisThe versatility of labelled cyanidePoster abstracts on the stability and storage of 14C‐labelled compoundsThe preparation of the P2 receptor agonist 2‐[methyl‐3H]methylthioadenosine‐5′‐diphosphateTritium labelling of aromatic and aliphatic aldehydes using Crabtree's catalyst, [Ir(cod)py(PCy3)]PF6The specific activity determination and confirmation of identity of a radiolabelled peptide using tandem mass spectrometryDesign and applicatoin of stable or radiolabelled carbamatesSynthesis of the various isotopomers of the MHC II antagonist AZD2315Synthesis of isotopomers of gefitinibMercuration/iododemercuration/deiodination: A practical first‐line strategy for the rapid preparation of iodinated labelling precursorsDeuterium labelling with cycloocta‐1,5‐dienyliridium(i)1,1,1,5,5,5‐hexafluoropentan‐2,4‐dionate: a comparison of D2o and d2 isotope donorsMartin D. Kamen (1913‐2002): The co‐discoverer of carbon‐14An efficient synthesis of [2‐14c] ethyl nipecotateRadiosynthesis conducted under cGMP complianceComputer‐simulations for the reactor‐synthesis of high‐activity, high specific activity, teletherapy sources of europium‐152Parallel optimisation of hydrogen isotope exchange mediated by homogeneous catalysts: A collaboration between the isotope groups at mölndal and charnwood R&DNew opportunities for isotope labelling using solid phase organic synthesisRapid synthesis of 11C‐flumazenil in a micro‐reactor placed in the hplc loop: A fast captive solvent methodSpatiotemporal imaging of receptor systems using pet