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The overall plaque burden and plaque phenotypes are associated with changes in the kinetics of miR-concentrations across the transcoronary passage. Transcoronary gradients of the anti-atherosclerotic miR-126-3p and miR-145-5p correlated with the extent of TCFAs, suggesting that instable plaques may affect the local uptake or degradation of these miRs.

ticular morphological features, which are differentially connected to the risk of plaque disruption and subsequent thrombus apposition, risk of vessel occlusion and acute coronary events. 2 Optical coherence tomography (OCT) is a light-based intravascular imaging modality that allows for high-resolution visualization of the coronary atherosclerotic plaques. 3 Currently, OCT provides the most detailed insights into plaque characteristics, allowing the measurement of lipid-pool extension and the thickness of the fibrous cap, as well as the identification of local plaque inflammation, all of which may represent key factors in A therosclerosis is a multifactorial disease that results from a complex interaction between genetic predisposition and well-recognized cardiovascular risk factors (CVRF), such as diabetes mellitus, arterial hypertension, hypercholesterolemia, smoking, obesity and age. The relationship between CVRF and the risk of experiencing a coronary event is widely acknowledged. 1 Nevertheless, the mechanisms underlying the role of individual risk factors in the development and progression of atherosclerotic plaques are currently not fully understood. Pathological and imaging studies have demonstrated that the morphological composition in large part reflects the fate of an atherosclerotic plaque. 2 It has been demonstrated that "stable" and "vulnerable" plaques show distinct and parEditorial p 1100 The association between cardiovascular risk factors (CVRF) and the risk of coronary events is widely acknowledged.Whether individual risk factors may be associated with distinct plaque characteristics is currently unclear. We investigated the relationship between CVRF and coronary plaque burden and phenotype.

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