OCT-derived coronary plaque morphology and transcoronary concentration gradients of vessel wall-associated microRNAs

Leistner, David M; Fichtlscherer, Stephan; Thome, Claudia; Boeckel, Niels; Roexe, Tino; Ardogan, M.; Lehmann, Ralf; Seeger, Florian; Dimmeler, Stefanie; Zeiher, Andreas M.

doi:10.1093/eurheartj/eht310.p5445

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Aging Calcification and Vessel Degeneration1

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“…9 Accordingly, a cardiac release of specific miRs (miR-145, miR-126) was shown in patients with "vulnerable plaques", identified by optical coherence tomography as those with high macrophage density or thin-cap fibroatheroma. 68 However, the usefulness of circulating miRs goes beyond the identification of patients at a higher risk of developing an acute coronary syndrome (ACS). In fact, as both cardiomyocytespecific (miR-208a) and muscle-enriched (miR-1, miR-133a/b, miR-499) miRs were described, several groups independently evaluated whether the measurement of their levels in the circulation could be useful to diagnose acute myocardial infarction.…”

Section: Aging Calcification and Vessel Degenerationmentioning

confidence: 99%

Emerging Role of MicroRNAs in Cardiovascular Diseases

Rosa

Curcio

Indolfi

2014

Circ J

104

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Section: Aging Calcification and Vessel Degenerationmentioning

confidence: 99%

Emerging Role of MicroRNAs in Cardiovascular Diseases

Rosa

Curcio

Indolfi

2014

Circ J

104

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Circulating microRNAs as Biomarkers in Cardiovascular Diseases

Rosa

Indolfi

2015

Experientia Supplementum

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MicroRNAs, key regulators of biological processes, are involved in the pathophysiological mechanisms underlying human diseases, including cardiovascular diseases. Their recent discovery revealed a previously unknown layer of pathophysiologic regulators, which also play a key role in the regulation of several aspects of cardiovascular diseases. More recently, it was demonstrated that circulating microRNAs can be measured in the blood. Hence, the potential use of microRNAs as disease biomarkers attracted many research groups. Indeed, their unusual stability in the bloodstream and during prolonged storage make circulating miRs very interesting as potential biomarkers. Circulating microRNAs are emerging as the next generation "smart" biomarkers and could be helpful in further improving the diagnostic and therapeutic processes of cardiovascular diseases. The present chapter summarizes the most relevant experimental evidence on circulating microRNAs in cardiovascular diseases, including arterial remodeling, restenosis, coronary artery disease, acute coronary syndromes, hypertension, heart failure, and ischemic stroke, highlighting potential pathophysiological correlations to the mechanisms underlying cardiovascular diseases.

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OCT-derived coronary plaque morphology and transcoronary concentration gradients of vessel wall-associated microRNAs

Cited by 2 publications

References 0 publications

Emerging Role of MicroRNAs in Cardiovascular Diseases

Emerging Role of MicroRNAs in Cardiovascular Diseases

Circulating microRNAs as Biomarkers in Cardiovascular Diseases

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