Performing patch tests in pizza makers and food handlers affected by hand contact dermatitis is useful. We propose a specific series of haptens for this wide working category.
Psoriasis is a well-established risk factor for psoriatic arthritis (PsA). 1,2 However, little is still known on the pathogenetic mechanisms that link psoriatic skin to joint inflammation, and how specific clinical characteristics could predict PsA onset. Cross-sectional population-based studies showed that psoriasis localization on specific body sites was associated with a greater risk: Patients with scalp lesions, nail dystrophy and intergluteal/perianal involvement had almost three times more risk to develop PsA. 3,4 Therefore, specific body site involvement seem to be important risk predictor of PsA onset.
| PREMIS E SPsoriatic arthritis is a heterogeneous disease characterized by inflammation and pathological bone remodelling in the joints. Chronic inflammation and local bone destruction are hallmarks of the disease. However, detailed bone changes in PsA have been evaluated only in a few studies. 5,6 Pathological bone remodelling in PsA depends on a varied array of cytokines, molecules and cellular interactions. In this scenario, the psoriatic skin plays its role. In previous research, we have demonstrated that psoriatic skin was able to release many factors with pro-osteoclastogenic action. In addition, our earlier results showed that the severity of cutaneous disease
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