The results of a paleomagnetic study along the fore arc of southern Peru (15–18°S) and northern Chile (18–19°S) are reported from middle to late Miocene ignimbrites (7 sites), late Oligocene to early Miocene ignimbrites (72 sites), Paleogene sediments (20 sites), and Mesozoic and Paleocene volcanics and intrusions (31 sites). Comparison of locality‐mean directions with expected paleomagnetic directions indicates vertical axis rotations ranging from 5.2 ± 11.3° clockwise to 55.6 ± 7.0° counterclockwise. Spatially, the magnitude of counterclockwise rotations increases northward from ∼0° within the Chilean fore arc south of 18°30′S to >45° north of 16°30′S. In southern Peru, paleomagnetic rotations recorded in Paleogene red beds decrease from late Eocene to late Oligocene, whereas Miocene ignimbrites display no evidence of rotation. These new results confirm that the rotations recorded in the fore arc of southern Peru were acquired at least before ∼15 Ma, and probably before 25 Ma, and thus prior to the late Neogene shortening of the sub‐Andes. The onset of major Andean shortening in the Eastern Cordillera during the latest Eocene–earliest Oligocene is interpreted to have triggered the bending of the Peruvian fore arc. The region of the Peruvian fore arc with the largest rotations appears to be the fore‐arc counterpart of the Abancay deflection, a remarkable NE‐SW offset in the axis of the Eastern Cordillera induced by a major regional preorogenic structure. We underline that the Abancay deflection should be seen as the northwestern boundary, and therefore as a key element, of the Bolivian Orocline.

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The cDNA coding for protein kinase CKla has been cloned from a Xenopus laevis cDNA library.The derived amino acid sequence of the protein contains 337 amino acids and has a calculated molecular mass of 38 874 Da. The sequence is identical to that of the human CKla and to the bovine CKla, except that it is 12 amino acids longer than the latter protein. Southern blotting with a 264-bp probe demonstrates that four or more fragments are obtained upon digestion of genomic DNA with EcoRl and Hind3, suggesting that X. Zaevis possesses a family of related CK1 genes. CKla was expressed in Escherichia coli as a glutathione transferase fusion protein (GT-CKIa) and certain of its characteristics were determined. The recombinant GT-CKla fusion protein was found to have apparent K,,, values for ATP (12 pM), casein (1.5 mg/ml) and the specific peptide substrate RRKDLHDDEEDEAMSITA (180 pM) which are similar to those of the rat liver CK1 enzyme. The recombinant CKla activity is weakly inhibited by heparin, but strongly inhibited by poly(GI~*":Tyr~~). This inhibition is competitive and shows an approximate K, of .5 pM. CKla can phosphorylate the tyrosine residues of poly(ClusO:Tyr'") and the tyrosine residue in the synthetic peptide RRREEEYEEEE. This kinase preparation also autophosphorylates in serine, threonine and weakly in tyrosine.

A cDNA clone coding for human protein kinase CKI (casein kinase 1) has been isolated and sequenced demonstrating that it corresponds to a homolog of the CKla form found in bovine brain. The derived amino acid sequence of the human CKlcl is identical to the bovine counterpart except that it contains I2 extra amino acids at the carboxyl end. Using this cDNA sequence and PCR amplification, YAC genomic clones that contain this human CKla sequence have been isolated. These YACs have been used for fluorescent in situ hybridization in order to localize the human CKla gene to chromosome 13q13.

2018) 'Mid-to late Pliocene (3.32.6Ma) global sea-level uctuations recorded on a continental shelf transect, Whanganui Basin, New Zealand.', Quaternary science reviews., 201 . pp. 241-260.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Abstract 35We present a ~900 m-thick, mid-(3.3-3.0 Ma) to late Pliocene (3.0-2.6 Ma), shallow-marine, 36 cyclical sedimentary succession from Whanganui Basin, New Zealand that identifies 37 paleobathymetric changes, during a warmer-than-present interval of Earth history, relevant 38 to future climate change. Our approach applies lithofacies, sequence stratigraphy and 39 benthic foraminiferal analyses to two continuously-cored drillholes integrated with new and 40 existing outcrop studies. We construct a depositional model of orbitally-paced, global sea-41 level changes on a wave-graded continental shelf. Unlike many previous studies, these shelf 42 sediments were not eroded during sea-level lowstands and thus provide the potential to 43 reconstruct the full amplitude of glacial-interglacial sea-level change. Paleobathymetric 44 interpretations are underpinned by analysis of extant benthic foraminiferal census data and 45 a statistical correlation with the distribution of modern taxa. In general, water depths 46 derived from foraminiferal Modern Analogue Technique (MAT), are consistent with 47 variability recorded by lithofacies. 48 The inferred sea-level cycles co-vary with a qualitative climate record reconstructed from a 49 census of extant pollen and spores, and a modern temperature relationship. A high-resolution 50 age model is established using magnetostratigraphy constrained by biostratigraphy, and the 51 dating and correlation of tephra. This integrated chronostratigraphy allows the recognition of 52 23 individual sedimentary cycles, that are correlated across the paleo-shelf and a possible 53 "one-to-one" relationship is made to orbital time series and the deep-ocean benthic oxygen 54 isotope (δ 18 O) record. In general water depth changes were paced by ~20 kyr duration 55 between 3.3-3.0 Ma, after which cycle duration is ~40 kyr during the late Pliocene (3.0-2.6 56 Ma). This record provides a future opportunity to evaluate the amplitude and frequency of 57 global, Pliocene glacio-eustatic sea-level change, independent of the global δ 18 O benthic 58 record. 59 60 1. Introduction 61 62 1.1 Pliocene climate and sea-level change 63 64 The mid-to late Pliocene (3.3-2.6 Ma) spans one of the most significant climatic transitions 65 of the Cenozoic. It is characte...