An improved procedure for the synthesis of tltreo-and erythro-B-hydroxy-DL-aspartic acids is described. An nuclear magnetic.res~nance study of both diastereomers indicated that the threo isomer exists primarily as the conformer having antr carboxyl groups while the erythro compound prefers a conformation with gauche carboxyl functions. Possible reasons for this anomaly are presented.

The agents evaluated demonstrated physical and chemical compatibility under conditions that would be observed during the administration of peridural anesthesia. Combinations of these drugs therefore could be safely admixed for use in anesthesia.

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