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It is unclear. With a two-week course of antibiotics, 80% to 90% of palpable low-risk nodes will resolve by 8 to 10 weeks (SOR: B, small prospective cohort study). However, guidelines discourage empiric antibiotics for asymptomatic lymphadenopathy of ,2 cm and instead recommend observation for regression and excisional biopsy for persistent lymphadenopathy that is still present after four to six weeks (SOR: C, clinical guidelines).