Objective: To investigate personality traits in patients with Alzheimer disease, compared with mentally healthy control subjects. We compared both current personality characteristics using structured interviews as well as current and previous personality traits as assessed by proxies. Method: Fifty-four patients with mild Alzheimer disease and 64 control subjects described their personality traits using the Structured Interview for the Five-Factor Model. Family members filled in the Revised NEO Personality Inventory, Form R, to evaluate their proxies' current personality traits, compared with 5 years before the estimated beginning of Alzheimer disease or 5 years before the control subjects. Results: After controlling for age, the Alzheimer disease group presented significantly higher scores than normal control subjects on current neuroticism, and significantly lower scores on current extraversion, openness, and conscientiousness, while no significant difference was observed on agreeableness. A similar profile, though less accentuated, was observed when considering personality traits as the patients' proxies remembered them. Diachronic personality assessment showed again significant differences between the 2 groups for the same 4 domains, with important personality changes only for the Alzheimer disease group. Conclusions: Group comparison and retrospective personality evaluation are convergent. Significant personality changes follow a specific trend in patients with Alzheimer disease and contrast with the stability generally observed in mentally healthy people in their personality profile throughout their lives. Whether or not the personality assessment 5 years before the current status corresponds to an early sign of Alzheimer disease or real premorbid personality differences in people who later develop Alzheimer disease requires longitudinal studies.

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This study highlights the negative but temporary association between critical events and QoL. However, a combination of high conscientiousness and extraversion, and positive social support may explain better variances for a high-perceived QoL.

We investigated the relationship between personality and quality of life (QoL) considering emotion regulation and self-efficacy beliefs as mediating factors. A total of 409 participants from the French-speaking regions of Switzerland and from France completed questionnaires on personality, emotion regulation, self-efficacy beliefs, and QoL. Our findings revealed that specific personality traits have significant direct and indirect effects on QoL, mediated by emotion regulation and self-efficacy. Particularly, neuroticism was strongly and negatively related to emotion regulation and QoL, but not significantly linked to self-efficacy, whereas extraversion and conscientiousness were positively associated with all variables. This is the first study to demonstrate that both emotion regulation and self-efficacy are important mechanisms that link specific personality traits to QoL, suggesting that they channel and modulate the personality effects. However, more work is needed to understand these relationships in more detail (e.g., how the personality traits concurrently influence each other as well as emotion regulation and self-efficacy).