Background: Calcium promotes gastric wound repair, but the in vivo mechanisms are unknown. Results: Signaling pathways sequentially mobilize intracellular and extracellular calcium as a requirement to repair gastric lesions. PMCA1 mediates extracellular calcium increases. Conclusion: Endogenous calcium is an essential second and third messenger driving gastric repair. Significance: Signaling and ion flux pathways are newly identified targets for enhancing gastric repair.

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