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Background: Glucose-regulated protein 78 (GRP78) is a plasminogen (Pg) and tissue-type plasminogen activator (t-PA) receptor on the cell surface. Results: Binding of t-PA to GRP78 stimulates its amidolytic activity, activation of Pg, and cell proliferation in vitro. Conclusion: Cell surface GRP78 enhances Pg activation by t-PA and mediates cell proliferation via binding to t-PA and microplasminogen. Significance: This complex may play a significant role in brain physiology.

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