Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the established factors influencing the metabolic flux, i.e., diet, lifestyle, antibiotics, xenobiotics, infectious agents, also the individual gut microbiota should be considered. A healthy gut microbiota contributes in maintaining human health by providing unique metabolic functions to the human host. Many patients with IEMs are on special diets, the main treatment for these diseases. Hence, IEMs represent a good model to evaluate how specific dietary patterns, in terms of macronutrients composition and quality of nutrients, can be related to a characteristic microbiota associated with a specific clinical phenotype (“enterophenotype”). In the present review, we aim at reporting the possible links existing between dysbiosis, a condition reported in IEMs patients, and a pro-inflammatory status, through an altered “gut-liver” cross-talk network and a major oxidative stress, with a repercussion on the health status of the patient, increasing the risk of non-communicable diseases (NCDs). On this basis, more attention should be paid to the nutritional status assessment and the clinical and biochemical signs of possible onset of comorbidities, with the goal of improving the long-term wellbeing in IEMs. A balanced intestinal ecosystem has been shown to positively contribute to patient health and its perturbation may influence the clinical spectrum of individuals with IEMs. For this, reaching eubiosis through the improvement of the quality of dietary products and mixtures, the use of pre-, pro- and postbiotics, could represent both a preventive and therapeutic strategy in these complex diseases.

Abstract. The use of moving devices equipped with range- and image-based sensor, generically defined Mobile Mapping systems (MMS), have been quite a disruptive innovation in the development of Geomatics techniques for 3D surveying large indoor-outdoor spaces and offer multiple solutions. The recent expansion of portable devices in the form of trolleys, backpacks, handheld tools largely implements SLAM (Simultaneous Localization and Mapping) algorithms and technology based on both Lidar and/or visual solutions for answering to the positioning and the 3D reconstruction problems. The research on MMS is directed to improve both multi-sensor integration implementation and usability of systems in diversified use contexts and application fields. The aim of the presented research is the evaluation of the potential of the Swift system recently developed by FARO Technologies, that has been fine-tuned for regular and large extent interiors mapping (such as factories, hospitals, airports, offices). The work tries to preliminary investigate the data delivery and usability of the integrated system. This is based on three elements mounted on a sliding trolley moved by the operator walking: the ScanPlan profilometer working for the 2D SLAM mapping, the static TLS Focus S-series, and the smartphone managing the sensors operation and the acquisition progress. The evaluation strategy undertaken will be based on the global and local performance analysis related to the trajectory, the data accuracy, the metric content and consistency. Two test studies belonging to the 20th century. architecture are presented in a preliminary framework of evaluation and validation: a Liberty-style cinema and the Torino Esposizioni Hall B designed in ferrocement by pier Luigi Nervi.

ABSTRACT:TLS (Terrestrial Laser Scanners) data today represents one of the most attractive ways to face the metric survey of an architectural object. When a restoration project is needed not many restorers are used to managing 3D models and traditional graphic results such as plans and sections are usually required. The paper defines a correct balance between the use of traditional (manual and total station) and TLS techniques in order to satisfy the usual requirements for the metric survey of an architectural object in order to obtain a complete 2D documentation of the San Giovanni Church in Saluzzo (Cn)-Italy that would be used for the restoration both of the decorative apparatus and of the structure of the church. Furthermore using the acquired 3D data some tests on commercial and open-source software for 3D modeling purpose are realised. The paper deals first of all with the followed methodology for the 2D documentation starting from 3D data. Moreover an analysis and a comparison between different software packages for the 3D modeling phase is reported.

Abstract. Mobile Mapping Systems (MMS) have recently benefited from the development of many fusion-based technologies with countless systems development based on cars, drones, trolley, wearable or portable mapping system. The scale of applicating range from the urban to the architectural scale. Recent solution are also based on visual or Lidar SLAM (Simultaneous Localization and Mapping), which substantially takes advantage of environmental features and techniques of continuous co-registration of the clouds, also in case of absence on GNSS positioning measurement. FARO Technology has recently developed the Swift, a fusion-based hybrid solution that integrates the sensors for 3D mapping in a trolley system configuration and recently, an external camera Panocam Theta Z1 is equipping the system enabling the possibility to associate radiometry to the acquired data. The working principle is the exploitation of a system of static and mobile configuration, using the so-called “anchor scans” co-registration as an hybrid intermediate solution between a typical static scan and a profilometers-based MMS point cloud. The co-registered clouds therefore yield a trajectory mode such as SLAM but benefit from the comparable range and density characteristics, according to user-customized settings, of static scans, with a duration of a few seconds per scan and a few minutes overall. In the present research the Swift System is tested in two different context and the assessment are conducted aimed at satisfying both the urban and the architectural scale instances in the direction of improving further evaluations.

Abstract. The documentation process of Built Heritage could be really challenging, and managing the different phases of this process is not always straightforward. The metric survey design is still one of the most complex and delicate tasks in the overall process: it drives the activities of data acquisition, processing, validation, interpretation, and final product delivery. It encompasses several aspects: stakeholders involvement, choice of instruments and techniques, available resources (not only economical but also in terms of human resources) timelines, etc. Moreover, a wrong or inaccurate metric survey design can lead to significant mistakes during the data acquisition phase that can result in the collection of redundant data or, worst-case scenario, a lack of data. After a brief state-of-the-art in the European and Italian framework, the research presented in this work will focus on the different aspects of the documentation process and, more specifically, on new digital tools that can assist this step of the Built Heritage documentation. More specifically, the contribution will focus on 360° cameras and the related cloud-based platforms for using and sharing these types of data. This market sector has been rapidly growing in the last years, and we faced a lowering of the purchase costs for these systems together with a wider availability of different sensors. Finally, the resolution has reached exciting levels with sensors that can record 360° data up to 6K/8K.