No abstract

No abstract

No abstract

The present paper reports on the formation and respectively shielding of TiO2 nanotubes elaborated in two water-containing organic electrolytes with the addition of NH4F, via potential step anodizing method. The organic compounds used ethylene glycol (EG) and polyethylene glycol (PEG), have significantly different molecular weights and viscosities. As a consequence, the resulting nanotubes layers are unshielded in first electrolyte and shielded in the second and have different diameters and lengths. FT-IR spectra reveal the incorporation of electrolyte anions to the surface of the TiO2 nanotubes when employing the most viscous electrolyte. This could be an explanation for different contact angle values, roughness and corrosion resistance in bioloquids.

Based on previously reported findings showing reduced foreign body reactions on nanochannelar topography formed on TiZr alloy, this study explores the in vitro effects of such a nanostructured surface on cells relevant for implant osseointegration, namely osteoblasts and osteoclasts. We show that such nanochannelar surfaces sustain adhesion and proliferation of mouse pre-osteoblast MC3T3-E1 cells and enhance their osteogenic differentiation. Moreover, this specific nanotopography inhibits nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. The nanochannels’ dual mode of action on the bone-derived cells could contribute to an enhanced bone formation around the bone implants. Therefore, these results warrant further investigation for nanochannels’ use as surface coatings of medical implant materials.