Purpose To compare surgery outcomes and safety of button bipolar enucleation of the prostate vs laparoscopic simple prostatectomy in patients with large prostates (> 80 g) in a two-center cohort study. Methods All patients with lower urinary tract symptoms due to benign prostatic enlargement (Prostate volume > 80 cc) undergoing button bipolar enucleation of the prostate (BTUEP) or laparoscopic simple prostatectomy (LSP) in two centers were enrolled. Data on clinical history, physical examination, urinary symptoms, uroflowmetry and prostate volume were collected at 0, 1, 3 6, 12, 24 and 36 months. Early and long-term complications were recorded. Results Overall, 296 patients were enrolled. Out of them, 167/296 (56%) performed a LSP and 129/296 (44%) performed a BTUEP. In terms of efficacy both procedures showed durable results at three years with a reintervention rate of 8% in the LSP group and of 5% in the BTUEP group. In terms of safety, BTUEP and LSP presented similar safety profiles with a 9% of transfusion rate and no major complications. Conclusion LSP and BTUEP are safe and effective in treating large-volume adenomas with durable results at three years when performed in experienced centers.

No abstract

No abstract

EGFR-20-CTF expression was < 16 months. GSEA showed that EGFR-20-CTF correlated with a significant decrease in expression of gene sets related to immune response including the HALLMARK inflammatory response, IL-2 signaling, and INF gamma response (all FDR q-val < 0.001).CONCLUSIONS: EGFR-20-CTF occurs frequently in patients with ccRCC and is enriched in patients who had a poor response to immunotherapy. The presence of the EGFR-20-CTF was associated with a global decrease in expression of several gene sets related to immune response, which could account for the decreased response to immunotherapy observed in these patients. This previously unrecognized splice variant presents a possible marker of resistance and will need prospective validation.